SOLID TUMORS

This early-phase study tests a new drug called M9140 in 12 Chinese patients with advanced colorectal cancer that has not responded to standard treatments. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The main goals are to check safety…

This early-stage trial tests a new drug called BI-1910, alone or with pembrolizumab, in people with advanced solid tumors (like lung or liver cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see how the body …

This early-stage study tests a new drug, JSI-1187, alone or with another drug (dabrafenib) in people with advanced solid tumors that have certain gene changes (MAPK pathway mutations). The main goal is to check safety and find the right dose. About 71 adults with tumors that have…

This study tests two different versions of the drug AZD2281 (a tablet and a capsule) in people with advanced solid tumors that have not responded to standard treatments. The main goal is to see which form is absorbed better by the body and to check their safety. About 197 partici…

This study tests a new experimental drug called XmAb24306, given alone or with another drug (atezolizumab), in people with advanced solid tumors that cannot be cured. The main goal is to check safety and find the best dose. About 195 adults with various solid tumors will take par…

This early-phase study tests a new cell treatment (GK01) combined with an immunotherapy drug (PD-1 antibody) in 15 adults with advanced solid tumors that have spread or come back. The main goal is to check safety and how the body handles the treatment, while also looking at wheth…

This early-stage trial tests an experimental drug called IMP321, which aims to boost the immune system's ability to fight cancer. It is given alongside standard treatments like chemotherapy or immunotherapy to people with advanced solid tumors that have spread. The main goal is t…

This study tests an experimental drug called ASTX660 in people with advanced solid tumors or lymphomas that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors or slow disease growth. About 253 adults will take part in …

This early-phase study tests an experimental mRNA cancer vaccine (mRNA-4157) in 161 people with solid tumors. The vaccine is designed to train the immune system to attack cancer cells. Some participants receive the vaccine alone, while others get it with the immunotherapy drug pe…

This study tests the safety and effectiveness of the drug pembrolizumab in preventing cancer from returning. It includes 17 adults with MSI-H solid tumors who had surgery but still have tumor DNA in their blood. Participants receive pembrolizumab or a placebo for up to 12 months,…

This study tests an experimental drug called entrectinib in children and teens with advanced solid tumors or brain cancers that have come back or not responded to other treatments. The goal is to find the safest dose and see if the drug can shrink tumors, especially in those with…

This study tests whether combining two drugs, olaparib and pembrolizumab, can shrink or control advanced solid tumors that have specific DNA repair defects. About 300 adults whose cancer has not responded to standard treatments will receive the combination. The goal is to see how…

This study tested whether ginseng can reduce fatigue and improve mood in 165 adults with advanced cancer. Participants took ginseng or a placebo for 29 days. The goal was to see if ginseng helps people feel less tired and more energetic during cancer treatment.

This study aims to learn why certain solid tumors stop responding to targeted therapies. Researchers will collect blood, saliva, and tumor tissue from 2500 people with various cancers, including colorectal, breast, lung, and rare tumors. By analyzing the genetic makeup of these s…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. About 1,200 adults aged 1…

This early-stage study looks at how the antibiotic rifampicin changes the way the body processes the experimental cancer drug cediranib in 64 adults with advanced solid tumors. Participants take both drugs so researchers can measure drug levels and check for side effects. The goa…