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Cancer drug safety tracked over years in ongoing study

NCT ID NCT03815643

Disease control Sponsor: EMD Serono Research & Development Institute, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study follows 205 people with solid tumors who are already taking the cancer drug avelumab. Researchers want to see how safe the drug is over the long term and how long patients live or stay cancer-free. Participants continue their current treatment or are monitored after finishing it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

205 people

The number who actually took part.

Started

Mar 2019

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants under enrollment and treatment in an avelumab clinical study under the sponsorship of EMD Serono Research \& Development Institute, Inc. / Merck KGaA, Darmstadt, Germany * Merck Serono Co., Ltd (Japan) * Participants currently enrolled in an avelumab parent study and are on active treatment with avelumab or in long-term survival follow-up after treatment * Participants on active treatment must agree to continue to use highly effective contraception (that is, methods with a failure rate of less than 1% per year) for both male and female participants if the risk of conception exists * Other protocol defined inclusion criteria could apply. Exclusion Criteria: * Participants who are pregnant or breastfeeding * Participants still on active treatment: Known hypersensitivity to any of the study intervention ingredients * Participant has been enrolled in the comparator arm of avelumab parent study * Participant has been withdrawn from avelumab parent study for any reason * Any other reason that, in the opinion of the Investigator, precludes the participant from participating in the study * Other protocol defined exclusion criteria could apply.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma ovarian cancer renal cell carcinoma transitional cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Solid tumors

Contacts and locations

Locations

  • Adana City Hospital - Parent Account

    Adana, Turkey (Türkiye)

  • Ankara University Medical Faculty - Medical Oncology

    Ankara, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, South Korea

  • Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli" - Dipartimento Oncologia

    Naples, Italy

  • BHI of Omsk region "Clinical Oncology Dispensary" - Building #2

    Omsk, Russia

  • BP Medical

    Vinnytsia, 21029, Ukraine

  • Ballarat Health Services

    Ballarat, Australia

  • CHU Besançon - Hôpital Jean Minjoz - Service d'oncologie Medicale

    Besançon, France

  • CHU Bordeaux - Service d'Oncologie Médicale

    Pessac, France

  • CHU Poitiers - Hôpital la Milétrie - service d'oncologie médicale

    Poitiers, France

  • CNE KHERSON REG ONCOLOGICAL DISPENSARY OF KHERSON RC - Day Hosp of Polycl with Outpatient Chemoth Room

    Kherson, Ukraine

  • Cancer Institute Hospital of JFCR - Dept of Respiratory Medicine

    Kōtoku, Japan

  • Centre Antoine Lacassagne - Service d'Hématologie Oncologie

    Nice, France

  • Centre Hospitalier de l'Ardenne - Pharmacie

    Libramont, Belgium

  • Centre Oscar Lambret - Service d'Oncologie medicale

    Lille, France

  • Centre Paul Strauss - Service de Médecine Oncologique

    Strasbourg, France

  • Chonnam National University Hwasun Hospital

    Daejeon, South Korea

  • Chungbuk National University Hospital

    Cheongju-si, South Korea

  • Clinique CHC MontLégia

    Liège, Belgium

  • Clínica Universitaria Privada Reina Fabiola

    Córdoba, Argentina

  • Derriford Hospital - Dept of Oncology Clinical Trials

    Plymouth, United Kingdom

  • Ege University Medical Faculty - PARENT

    Izmir, Turkey (Türkiye)

  • FSBI "National Medical Research Center for Oncology n.a. N.N. Petrov" of the MoH of the RF - Parent

    Saint Petersburg, Russia

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica

    Roma, Italy

  • Gachon University Gil Medical Center

    Incheon, South Korea

  • Goztepe Prof. Dr. Suleyman Yalcin City Hospital - Medical Oncology

    Istanbul, Turkey (Türkiye)

  • Greenville Hospital System University Medical Center (ITOR) - Upstate Affiliate Organization

    Greenville, South Carolina, 29605, United States

  • Groupe Hospitalier Sud - Hôpital Haut-Lévêque - Unité d'Explorations Fonctionnelles Respiratoires

    Pessac, France

  • Hacettepe University Medical Faculty - Oncology

    Ankara, Turkey (Türkiye)

  • Health Pharma Professional Research S.A. de C.V.

    México, Mexico

  • Hematology - Oncology Associates of the Treasure Coast - Hematology-Oncology Associates of Treasure Coast

    Port Saint Lucie, Florida, 34952, United States

  • Henry Ford Hospital

    San Antonio, Texas, 78229, United States

  • Highlands Oncology Group

    Fayetteville, Arkansas, 72703, United States

  • HonorHealth Research Institute

    Scottsdale, Arizona, 85258, United States

  • Hopital Larrey - Service de Pneumologie et Oncologie Thoracique

    Toulouse, France

  • Hospital General Universitario Gregorio Marañon - Servicio de Oncologia Medica

    Madrid, Spain

  • Hospital Universitari Vall d'Hebron - Oncology Dept.

    Barcelona, Spain

  • Hospital de Câncer de Barretos - Fundação Pio XII

    Barretos, Brazil

  • Hospital de Mataro - Servicio de Oncologia Medica

    Mataró, Spain

  • Hospital de la Santa Creu i Sant Pau - Dept of Oncology

    Barcelona, Spain

  • ICO - Site Paul Papin - service d'oncologie medicale

    Nantes, France

  • ICO - Site René Gauducheau - Service d'Oncologie medicale

    Nantes, France

  • IOV - Istituto Oncologico Veneto IRCCS

    Padova, Italy

  • Institut Curie - site de Paris - Service d'Oncologie Médicale

    Paris, France

  • Instituto Alexander Fleming

    Ciudad Autonoma Buenos Aires, Argentina

  • Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj Napoca - Sectia Radioterapie III

    Cluj-Napoca, Romania

  • Institutul Regional de Oncologie Iasi - Sectia Oncologie Medicala

    Iași, Romania

  • Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty - Medical Oncology

    Istanbul, Turkey (Türkiye)

  • Istituto Clinico Humanitas - U.O. di Oncologia Medica ed Ematologia

    Rozzano, Italy

  • Istituto Nazionale Tumori Regina Elena IRCCS - UOC Oncologia Medica A

    Roma, Italy

  • Kansas City Research Institute, LLC - Phase I Unit

    Kansas City, Missouri, 64131, United States

  • Korea University Anam Hospital

    Seoul, South Korea

  • Kurume University Hospital - Dept of Lung Cancer Center

    Kurume-shi, Japan

  • LLC "Medical Technologies" - Parent

    Saint Petersburg, Russia

  • MHAT for women's health - Nadezhda, OOD

    Sofia, Bulgaria

  • Maryland Oncology Hematology, P.A.

    Rockville, Maryland, 20850, United States

  • Masarykuv onkologicky ustav - 300176866 Parent

    Brno, Czechia

  • Medical University of South Carolina (MUSC)

    Charleston, South Carolina, 29425, United States

  • Medipol University Medical Faculty - Parent

    Istanbul, Turkey (Türkiye)

  • Mersin University Medical Faculty - Medical Oncology

    Mersin, Turkey (Türkiye)

  • Michigan State University

    Lansing, Michigan, 48910, United States

  • Monash Medical Centre Clayton

    Clayton, Australia

  • Mount Vernon Cancer Centre

    Northwood, United Kingdom

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy - Dept of Lungs and Chest Oncology

    Warsaw, Poland

  • National Cancer Center

    Goyang, South Korea

  • National Cancer Center Hospital (NCCH)

    Chūōku, Japan

  • National Cancer Center Hospital - Dept of Gastrointestinal Oncology

    Chūōku, Japan

  • Nemocnice Rudolfa a Stefanie Benesov a.s. nemocnice Stredoceskeho kraje - parent

    Benešov, Czechia

  • Northwest Georgia Oncology Centers

    Marietta, Georgia, 30060, United States

  • Norwalk Hospital - The Whittingham Cancer Center

    Norwalk, Connecticut, 06850, United States

  • OSU - James Comprehensive Cancer Center

    Columbus, Ohio, 43210-1228, United States

  • Oncology Consultants, P.A.

    Houston, Texas, 77030, United States

  • Oncology Hematology Care

    Cincinnati, Ohio, 45242, United States

  • Oncology/Hematology Care Clinical Trials, LLC

    Cincinnati, Ohio, 45242, United States

  • Oregon Health & Science University

    Portland, Oregon, 97201, United States

  • Osaka City General Hospital - Dept of Clinical Oncology

    Osaka, Japan

  • Osaka Habikino Medical Center - Dept of Pulmonary Oncology

    Habikino-shi, Japan

  • Osaka University Hospital - Dept of Gastrointestinal Surgery

    Suita-shi, Japan

  • Pavlov First Saint Petersburg State Medical University - PARENT

    Saint Petersburg, Russia

  • Petz Aladar Egyetemi Oktato Korhaz - Pulmonologiai Osztaly

    Győr, Hungary

  • Podilskyi Regional Oncological Center - Dept of Chemotherapy

    Vinnytsia, Ukraine

  • Providence Medical Foundation

    Santa Rosa, California, 95403, United States

  • RBIH "Kursk regional clinical oncology dispensary" of Kursk Region Healthcare Committee

    Kursk, Russia

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • S.C Oncomed S.R.L - Specialitatea Oncologie Medicala

    Timișoara, Romania

  • S.C Radiotherapy Center Cluj S.R.L - Parent

    Comuna Floresti, Romania

  • SBHI of Novosibirsk region "Novosibirsk Regional Oncological Dispensary"

    Novosibirsk, Russia

  • SCRI - Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • Samsung Medical Center

    Seoul, South Korea

  • Sarah Cannon Research Institute UK

    London, United Kingdom

  • Seoul National University Hospital

    Seoul, South Korea

  • Songklanagarind Hospital - Department of Medicine

    Songkhla, Thailand

  • Spitalul Clinic Municipal "Dr. Gavril Curteanu" Oradea - Centrul Oncologie Medicala

    Oradea, Romania

  • St Joseph Heritage Healthcare

    Santa Rosa, California, 95403, United States

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, South Korea

  • The West Clinic

    Germantown, Tennessee, 38138, United States

  • Tohoku University Hospital

    Sendai, Japan

  • Universitaetsklinikum Essen - Westdeutsches Tumorzentrum

    Essen, Germany

  • University of California Davis Health System - Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Cincinnati - PARENT

    Cincinnati, Ohio, 45229, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-8857, United States

  • University of Vermont Medical Center - Fletcher Allen Gastroenterology

    Burlington, Vermont, 05401, United States

  • Virginia Piper Cancer Institute

    Minneapolis, Minnesota, 55407, United States

  • Zala Varmegyei Szent Rafael Korhaz - Pulmonologiai Osztaly

    Zalaegerszeg, Hungary

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