Emd Serono Research & Development Institute, Inc.

This study tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to check safety and find the right dose, while also see…

This early-phase study tests a new drug called M3554 in people with advanced solid tumors, specifically soft tissue sarcoma and a type of brain cancer (glioblastoma). The main goals are to find the safest dose and check for side effects. About 52 participants will receive the dru…

This study tests a new drug called precemtabart tocentecan, alone or with bevacizumab, against a standard treatment for metastatic colorectal cancer that has not responded to prior therapies. About 1,020 adults who have already tried several standard treatments will participate. …

This study tests an experimental drug called enpatoran for people with lupus who have active skin rashes. About 202 participants will receive either enpatoran or a placebo on top of their usual treatments for 24 weeks. The goal is to see if the drug can significantly reduce skin …

This study tests an experimental drug called M9140 in people with advanced solid tumors (gastric, lung, or pancreatic cancer) that have a specific protein called CEACAM5. The drug is designed to deliver a chemotherapy-like payload directly to cancer cells. The trial aims to see i…

This early-stage study tests a new drug called M0324 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to target cancer cells and boost the immune system. Researchers will test M0324 alone, with another immunotherapy (pembro…

This early-stage study tests a new drug called M9140 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works by attaching a chemotherapy agent to an antibody that seeks out cancer cells. The study aims to find the safest dose and se…

This study tests an experimental drug called enpatoran for people with lupus that causes active skin rashes or sores. About 202 adults with lupus skin disease will receive either enpatoran or a placebo for 24 weeks, while continuing their usual treatments. The goal is to see if e…

This study is a disease registry that collects information from about 700 people with advanced non-small cell lung cancer that has a specific genetic change called METex14 skipping. The goal is to track what treatments people receive in everyday practice and how well they work, a…