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New registry aims to map treatment landscape for rare lung cancer mutation

NCT ID NCT05376891

Knowledge-focused Sponsor: EMD Serono Research & Development Institute, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 16, 2026 · Updated 7 times

Summary

This study is a disease registry that will follow about 700 people with advanced non-small cell lung cancer that has a specific genetic change called METex14 skipping. Researchers will collect information on patient characteristics, treatments, and outcomes over time to better understand how this cancer is managed in the real world. The goal is to gather high-quality data to inform future care, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 700 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with advanced stage (stages IIIB-IV) NSCLC and confirmed METex14 skipping alterations who are initiating or already treated with a systemic therapy will be included.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants who signed ICF * Participants with advanced stage (stages IIIB-IV) NSCLC (all histologies) and Confirmed METex14 skipping alterations (by valid assay) * Participants who are starting or are already being treated with systemic therapy Exclusion Criteria: * Participants who are enrolled in a clinical trial

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Advanced non-small cell lung cancer with MET exon 14 skipping alterations are added.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    74 sites in 14 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AOU dell'Università degli Studi della Campania Luigi Vanvitelli

    RECRUITING

    Naples, Italy

  • AZ Delta

    RECRUITING

    Roeselare, Belgium

  • AZ Nikolaas

    RECRUITING

    Sint-Niklaas, Belgium

  • Azienda Ospedaliera Dei Colli - Ospedale Monaldi

    RECRUITING

    Naples, 80131, Italy

  • Azienda Ospedaliero Universitaria di Modena

    RECRUITING

    Modena, 41125, Italy

  • Azienda Sanitaria Ospedaliera S Luigi Gonzaga

    RECRUITING

    Torino, Italy

  • Bedford General Hospital

    RECRUITING

    Bedford, United Kingdom

  • Birmingham Heartlands Hospital

    TERMINATED

    Birmingham, United Kingdom

  • Bnei-Zion Medical Center

    RECRUITING

    Haifa, Israel

  • British Columbia Cancer Agency (6864)

    RECRUITING

    Vancouver, V5Z 4E6, Canada

  • CHRU Lille

    RECRUITING

    Lille, France

  • CHU de Pontchaillou

    RECRUITING

    Rennes, 35 033, France

  • CHU de Toulouse Hopital Larrey

    RECRUITING

    Toulouse, France

  • Carmel Medical Center

    RECRUITING

    Haifa, Israel

  • Centre Hospitalier de Cholet

    RECRUITING

    Cholet, France

  • Centre Intégré de Cancérologie du CHU de Québec

    RECRUITING

    Québec, G1J0J9, Canada

  • Centre Leon Berard

    RECRUITING

    Lyon, France

  • Centro Hospitalar de Lisboa Norte, EPE - Hospital de Santa Maria

    RECRUITING

    Lisbon, Portugal

  • Centro Hospitalar do Porto E.P.E. Hospital de Santo António

    RECRUITING

    Porto, Portugal

  • Centro Integral Oncologico Clara Campa

    RECRUITING

    Madrid, Spain

  • Centro Oncologico MD Anderson

    TERMINATED

    Madrid, Spain

  • Chaim Sheba Medical Center

    RECRUITING

    Ramat Gan, Israel

  • Charing Cross Hospital

    RECRUITING

    London, United Kingdom

  • Clatterbridge Cancer Centre - Liverpool

    RECRUITING

    Liverpool, United Kingdom

  • Clinica Tres Torres

    RECRUITING

    Barcelona, Spain

  • Cliniques UCL de Mont-Godinne (7077)

    RECRUITING

    Yvoir, 5530, Belgium

  • Complejo Hospitalario Universitario Insular-Materno Infantil

    TERMINATED

    Las Palmas de Gran Canaria, Spain

  • Erasmus MC

    RECRUITING

    Rotterdam, South Holland, 3015 GD, Netherlands

  • FN Olomouc

    RECRUITING

    Olomouc, Czechia

  • Great Western Hospital

    RECRUITING

    Swindon, SN3 6BB, United Kingdom

  • Groupe Hospitalier Paris Saint Joseph

    RECRUITING

    Paris, 75014, France

  • Guy's Cancer Centre

    NOT_YET_RECRUITING

    London, SE1 9RT, United Kingdom

  • Haemek Medical Center

    RECRUITING

    Afula, Israel

  • Holy Cross Health

    RECRUITING

    Fort Lauderdale, Florida, 33308-4603, United States

  • Hospidal Universitario Ntra. Sra. De Valme

    RECRUITING

    Seville, Spain

  • Hospital Regional Universitario de Malaga - Hospital General

    RECRUITING

    Málaga, Spain

  • Hospital Tenon & University Paris 6

    RECRUITING

    Paris, France

  • Hospital Universitari i Politecnic La Fe de Valencia

    RECRUITING

    Valencia, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, Spain

  • Huddersfield Royal Infirmary

    NOT_YET_RECRUITING

    Huddersfield, West Yorkshire, HD3 3EA, United Kingdom

  • Hôpital du Scorff

    RECRUITING

    Lorient, France

  • I.F.O. Istituto Nazionale Tumori Regina Elena IRCCS

    RECRUITING

    Rome, Italy

  • Institut Curie - Centre de Lutte Contre le Cancer (CLCC)

    RECRUITING

    Paris, France

  • Institut Universitari Dexeus-Quiron - Servei d oncologia medica - Institut Oncologic Dr. Rosell

    TERMINATED

    Barcelona, Spain

  • Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS

    RECRUITING

    Porto Covo, Portugal

  • Istituto Europeo di Oncologia

    RECRUITING

    Milan, Italy

  • Istituto Nazionale Dei Tumori

    RECRUITING

    Milan, Italy

  • Jessa Ziekenhuis

    RECRUITING

    Hasselt, 3500, Belgium

  • KKH Grosshansdorf GmbH

    RECRUITING

    Großhansdorf, Germany

  • Klinik Floridsdorf

    RECRUITING

    Vienna, Austria

  • Klinik Löwenstein GmbH

    RECRUITING

    Löwenstein, Germany

  • Klinikum Chemnitz GmbH

    RECRUITING

    Chemnitz, Germany

  • Klinikum Klagenfurt Am Woerthersee

    RECRUITING

    Klagenfurt, Austria

  • Landeskrankenhaus Salzburg - Universitätsklinikum der PMU

    RECRUITING

    Salzburg, 5020, Austria

  • Leiden University Medical Center

    RECRUITING

    Leiden, Netherlands

  • Northwick Park Hospital

    RECRUITING

    Harrow, United Kingdom

  • Ospedale di Circolo

    RECRUITING

    Varese, Italy

  • Ottawa Hospital General Campus

    RECRUITING

    Ottawa, Canada

  • Preston Hospital

    RECRUITING

    Preston, United Kingdom

  • Princess Margaret Cancer Centre

    RECRUITING

    Toronto, Canada

  • Queen Elizabeth Hospital,Woolwich

    RECRUITING

    London, SE18 4QH, United Kingdom

  • Rabin Medical Center Oncology Beilinson Campus

    RECRUITING

    Petah Tikva, Israel

  • Rambam Medical Center - PPDS

    RECRUITING

    Haifa, Israel

  • Royal Bournemouth Hospital

    RECRUITING

    Bournemouth, United Kingdom

  • Shaare Zedek Medical Center

    RECRUITING

    Jerusalem, Israel

  • St. George's Hospital

    RECRUITING

    London, SW17 0QT, United Kingdom

  • Tel Aviv Sourasky Medical Center

    RECRUITING

    Tel Aviv, Israel

  • The Ohio State University Wexner Medical Center

    RECRUITING

    Columbus, Ohio, 43221, United States

  • The Royal Marsden Hospital

    RECRUITING

    Chelsea, United Kingdom

  • Thoraxklinik-Heidelberg gGmbH

    RECRUITING

    Heidelberg, Germany

  • Torbay Hospital

    RECRUITING

    Torquay, Devon, TQ2 7AA, United Kingdom

  • ULS de Loures-Odivelas, EPE - Hospital de Loures

    RECRUITING

    Loures, Lisbon District, 2674-514, Portugal

  • Universitair Medisch Centrum Groningen - Department of Medical Oncology

    RECRUITING

    Groningen, Netherlands

  • Universitetssjukhuset i Linköping

    RECRUITING

    Linköping, Sweden

  • University Hospital Na Bulovce

    RECRUITING

    Prague, Czechia

  • VU Medisch Centrum

    RECRUITING

    Amsterdam, Netherlands

  • Vanderbilt University Medical Center

    ACTIVE_NOT_RECRUITING

    Nashville, Tennessee, 37212, United States

  • Velindre Cancer Centre

    RECRUITING

    Cardiff, CF14 2TL, United Kingdom

  • Z.O.L. Campus Sint Jan (975)

    RECRUITING

    Roosendaal, 4708, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.