EMD Serono Research & Development Institute, Inc.

This early-phase study tests a new drug called M9466, a PARP1 inhibitor, alone or combined with other drugs in 60 people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and how the body processes the drug. Researchers …

This phase 2 trial tests whether adding avelumab (an immunotherapy) to another anti-cancer drug (sacituzumab govitecan) can help prevent advanced bladder cancer from growing after initial chemotherapy. About 256 participants with locally advanced or metastatic urothelial carcinom…

This early-phase trial tests a new drug called tuvusertib, given alone or with another drug (niraparib), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see early signs of tumor…

This study tests a new drug called M9140 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works by targeting a protein on cancer cells to deliver a chemotherapy-like agent directly to the tumor. The trial has two parts: first findi…

This study tests an experimental drug called M9140 in people with advanced solid tumors (gastric, lung, or pancreatic cancer) that have a specific protein (CEACAM5). The drug is designed to deliver a toxin directly to cancer cells. About 250 adults will receive the drug alone or …

This trial tested the drug tepotinib in 337 people with advanced non-small cell lung cancer that has specific MET gene changes (METex14 skipping or MET amplification). Participants took a 500 mg pill once daily. The main goal was to see if the drug could shrink tumors. The study …

This study follows 205 people with solid tumors who are already taking the cancer drug avelumab. Researchers want to see how safe the drug is over the long term and how long patients live or stay cancer-free. Participants continue their current treatment or are monitored after fi…