Can healthy donor cells shrink tumors? new trial aims to find out

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Subjects: * Must have signed Subject Informed Consent form * Documentation of Disease: All patients must have histologically or cytologically confirmed non-hematological malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective. * Measurable Disease: Lesions that can be accurately measured in at least one dimension (longest diameter recorded) as ³20 mm with conventional technique or as ³10 mm with spiral CT scan. * Life expectancy of at least 4 months as judged by the PI at the time of consent * Performance status of ≤2 on the ECOG scale (see Appendix I). * ≥ 4 weeks since prior medical therapy, radiation therapy, and surgery * Adequate organ function, such as absolute neutrophils ≥1,500/µl, platelet transfusion independent, * platelet count ≥100,000/µl, serum bilirubin ≤2 mg/dl, AST/ALT less than 3x upper limit of normal and serum creatinine ≤2 mg/dl. Exclusion criteria: * Uncontrolled diabetes mellitus, significant cardiac disease, e.g. recent myocardial infarction ≥ within 30 days, or active serious infection. * HIV infection and no recent use (within 30 days) of immunosuppressive agents other than steroids. * Pregnant or nursing women. * Men or Women of reproductive age who are not using an effective means of birth control. * Women of childbearing potential who have a positive serum pregnancy test prior to treatment. * HLA Class I \& II antibodies. * Neutrophil antibody test. * Prior history of stem cell transplantation. * Evidence of brain tumors or metastases. * Prior history of fludarabine therapy. Inclusion Criteria for Granulocyte Donors: * Must have signed Donor-participant Informed Consent Form * Must be a healthy, eligible blood donor who has completed Full-Length Universal Donor History Questionnaire version 1.2 * Must be able to donate granulocytes and be willing to undergo granulocyte apheresis * Must have an HLA profile (A, B, DR) with results that ensure donated granulocytes will be mismatched with the recipient * Must have CMV negative or positive sero-testing completed; only seronegative donors are accepted for a seronegative recipient * Must have compatible ABO and RH typing with the subject * Must be negative for HLA Class I \& II antibodies Exclusion criteria: * Positive Neutrophil antibody test * Positive infectious disease workup within 30 days of apheresis / donation. * Positive known cardiac illness that could cause a potential risk associated with leukapheresis. * Genetic relationship to the recipient