SLE

This early-phase study tests whether a new drug, ONTO1, is safe and tolerable for people with lupus nephritis or systemic lupus erythematosus (SLE). Researchers will also see if adding ONTO1 to standard lupus treatments can improve symptoms. The study enrolls 61 adults with activ…

This study tests a new cell therapy called CART19 for teens and young adults (ages 12-29) with severe lupus that hasn't responded to other treatments. The therapy uses the patient's own immune cells to target and reduce lupus activity. The goal is to control the disease and reduc…

This early-phase study tests a new treatment called RD06-05, which uses a patient's own immune cells modified to target and calm overactive immune responses in autoimmune diseases like lupus, scleroderma, and multiple sclerosis. The main goal is to check safety and how the body h…

This study is testing a new drug called APG-2575 in 40 people with mild-to-moderate systemic lupus erythematosus (SLE). The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor …

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm overactive immune responses in people with autoimmune diseases like lupus, vasculitis, and scleroderma. The main goal is to check safety and …

This early-stage study tests a new medicine, SAR448501/DR-0201, in adults with lupus or rheumatoid arthritis. The goal is to find safe and tolerable doses by checking side effects and how the drug works in the body. About 62 participants will receive multiple doses and be followe…

This early-stage study tests a new drug called CLN-978 in 24 people with moderate to severe systemic lupus erythematosus (SLE). The goal is to see if the drug is safe and how it affects the body, including reducing immune cells linked to the disease. Participants receive the drug…

This early-stage study tests a single injection of cells from donated umbilical cords in 10 adults with active lupus. The goal is to see if the treatment is safe and can improve kidney function and reduce disease activity when added to standard care. Participants will have regula…

This study tests an experimental drug called VENT-03 in 24 adults with active cutaneous lupus (skin lupus), with or without systemic lupus. Participants take VENT-03 or a placebo for 4 weeks, then everyone gets VENT-03 for 8 more weeks. The goal is to see if the drug reduces skin…

This study looks back at the pregnancy history of 50 women who were later diagnosed with lupus. The goal is to find out how often pregnancy problems like miscarriage or preterm birth happen before the lupus diagnosis. By understanding these early signs, doctors may be able to spo…