SLE

This early-stage study tests a new treatment called AB-101, made from natural killer cells, for people with severe lupus that hasn't responded to standard therapies. The treatment is given alone or with a B-cell depleting antibody to try to control the disease. The main goals are…

This study tests an experimental drug called ESK-001 in adults with lupus (SLE). The goal is to see if it can reduce disease activity better than a placebo over 48 weeks. About 408 participants who have active lupus and are on standard treatments will receive either ESK-001 or a …

This early-phase trial aimed to test a CD19-targeted CAR-T cell therapy (RD06-04) in people with autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis. The goal was to see if the treatment was safe and could reduce disease activity. However, the study was with…

This study looks at whether lupus flares cause swelling in the heart muscle. Researchers will use cardiac MRI to check for inflammation during a flare and again 3 months later. The goal is to better understand how lupus affects the heart. The study involves 40 adults with active …