RENAL IMPAIRMENT

This study tests a device called JuxtaFlow that helps protect the kidneys during heart surgery. People with kidney problems who need heart surgery are at higher risk for kidney damage afterward. The device gently reduces pressure inside the kidney to help it work better during th…

This study looks at how the drug eloralintide is processed by the body in people with severe kidney disease or kidney failure compared to healthy people. About 28 adults will receive a single injection under the skin. The study lasts about 14 weeks and aims to understand drug lev…

This study looks at how the body handles a new drug called S-892216 in people with mild, moderate, or severe kidney problems, including those on dialysis, compared to people with healthy kidneys. About 40 adults will take a single dose of the drug, and researchers will measure dr…

This study looks at how a single dose of the experimental drug combination bemnifosbuvir/ruzasvir behaves in people with severe kidney or liver problems compared to healthy people. About 28 adults will take one dose and have their blood tested to measure drug levels and safety. T…

This study looks at how a new medicine called PF-07328948 moves through the body and how safe it is in people with normal or reduced kidney function. About 28 adults aged 18 to 80 will take a single dose by mouth and stay at a research unit for 6 days. The results will help docto…

This early-stage study looks at how the drug MK-2828 behaves in people with different levels of kidney function, including those with severe kidney failure or on dialysis. About 24 adults will receive one or two doses, and researchers will measure drug levels in the blood over ti…

This study looks at how the drug opemalirsen behaves in people with different levels of kidney function. About 50 adults aged 18 to 80 will receive a single dose, and researchers will measure drug levels in the blood. The goal is to understand safety and dosing, not to treat any …