RECTAL CANCER PATIENTS

This study tests a combination of chemotherapy, radiation, and immunotherapy (PD-1 therapy) given before surgery for people with locally advanced rectal cancer that has a high chance of coming back. The goal is to see if this approach can completely eliminate the tumor before sur…

This study tests whether adding an immunotherapy drug (QL1706) to standard chemotherapy and radiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 108 participants will be randomly assigned to receive either the standard treatment or t…

This study tests whether adding a weight-loss medication (GLP-1 drug) to standard chemotherapy and radiation before surgery helps rectal cancer patients with a high BMI. About 42 participants will either receive the drug plus standard therapy or standard therapy alone. Researcher…

This study tests whether adding a citrus flavonoid tablet (Aimailang) to standard chemotherapy (mFOLFOX6) can shrink advanced rectal tumors more effectively before surgery. About 236 adults with a specific genetic marker (high YWHAB) will be randomly assigned to get chemo with or…

This study tests a new approach for adults with locally advanced rectal cancer that hasn't spread. Participants get a short course of radiation followed by a mix of two chemotherapy drugs and an immunotherapy drug. The goal is to shrink the tumor enough so that surgery may not be…

This study looks at 100 people with rectal cancer who received total neoadjuvant therapy (a combination of chemotherapy and radiation before surgery). Researchers want to see whether the status of lymph nodes after treatment or the shrinkage of the main tumor better predicts how …

This study looks at two ways to remove rectal cancer using minimally invasive surgery. One method removes the tumor through the anus, avoiding extra cuts in the belly. The other uses a small belly cut. Researchers want to see if the newer method leads to fewer wound problems and …