PROSTATE CANCER (ADENOCARCINOMA)

This study is testing a two-step treatment for men with high-risk prostate cancer that hasn't spread. First, patients receive a single, strong dose of targeted radiation directly to the prostate. Four to eight weeks later, they have robotic surgery to remove the prostate. Some pa…

This study is testing whether adding one or two common medications (dexamethasone and metronidazole) to a standard prostate cancer drug (abiraterone) can help overcome drug resistance. It aims to help men whose metastatic prostate cancer has stopped responding to abiraterone. The…

This study is testing whether a combination of two drugs—an antibody-drug conjugate and an immunotherapy drug—can help control aggressive forms of prostate cancer that have stopped responding to standard hormone therapies. It will enroll 28 men in China with advanced, fast-growin…

This study is testing whether a single, high-precision dose of radiation can treat prostate cancer with similar side effects as the standard five-session treatment. It will involve 58 men with intermediate or high-risk prostate cancer that hasn't spread. Researchers will carefull…

This study is testing whether a more responsive form of radiation therapy is better for treating localized prostate cancer. It compares standard radiation planning to an 'adaptive' approach that checks the position of nearby organs (like the bladder and rectum) before each treatm…

This study is testing whether doctors can safely lower the radiation dose to healthy parts of the prostate to reduce side effects, while still giving a high dose to visible tumors to control cancer. It compares two approaches in men with low or intermediate-risk prostate cancer. …

This study is testing a minimally invasive laser procedure for men with intermediate-risk prostate cancer. Doctors use a special, high-resolution ultrasound to guide a laser that precisely heats and destroys the tumor. The goal is to see if this targeted approach is safe and effe…

This study is testing whether a shorter, 5-week course of targeted radiation is safe and effective for men with prostate cancer who also have bothersome urinary symptoms or an enlarged prostate. It aims to see if this approach can control the cancer while keeping severe side effe…

This large international study is testing if adding a chemotherapy drug (docetaxel) to the standard hormone therapy helps men with advanced prostate cancer that has spread. The goal is to see if this combination can better control the cancer and help patients live longer compared…

This study is testing whether giving two hormone-blocking drugs (darolutamide and relugolix) before prostate removal surgery is safe and can shrink tumors in men with high-risk prostate cancer. The trial will enroll about 30 men to see if they can complete the drug treatment with…

This early-stage study is testing a new oral medication called HLD-0915 for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The main goals are to find a safe dose and see if the drug can help control the cancer. The stu…

This is the first study in people to test a new drug called ACE-232 for men with metastatic prostate cancer that has stopped responding to standard hormone therapy. The main goal is to find a safe dose and see how the body handles the drug. Researchers will also look for early si…

This study is testing whether a 3D virtual reality model, built from a patient's pre-surgery scan, can help surgeons more accurately find and remove prostate cancer that has spread to lymph nodes. It involves 102 men with prostate cancer who are scheduled for surgery. Researchers…

This study is testing a more precise type of radiation therapy for men with intermediate-risk prostate cancer. The goal is to see if adjusting the radiation dose in real-time based on daily scans can better target the tumor while reducing damage to nearby organs like the bladder …

This study is testing a new gene therapy approach for men with intermediate-risk prostate cancer who are scheduled for radiation treatment. The therapy involves injecting a modified virus into the prostate, followed by taking an oral antiviral pill, to try to kill cancer cells an…

This study is testing whether adding enzalutamide to talazoparib works better than talazoparib alone for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The trial includes 126 men whose cancer has specific genetic changes and …

This study is testing how well a special type of PET scan can find prostate cancer that has come back after surgery, specifically in men whose PSA blood test shows only a very tiny increase. Researchers will give the scan to about 50 men who have had their prostate removed and no…

This study is testing a new type of PET scan that uses a special tracer to detect prostate cancer. Researchers will compare how well this new scan finds cancer inside the prostate compared to the current standard MRI scan. The study involves 50 men with newly diagnosed prostate c…

This study aims to see if a new type of PET scan is as good as or better than the standard MRI scan at finding prostate cancer. It will involve 100 men who are newly diagnosed and scheduled for surgery to remove their prostate. Researchers will compare how accurately each scan fi…

This study is testing if adding a special scan called a PSMA PET to the usual MRI can better detect if prostate cancer returns in men who have had focal therapy. Researchers will follow 62 men for about a year after their treatment to compare how well the two scans find returning…

This study is testing two new imaging probes (68Ga-G21 and 68Ga-G23) to see if they can help doctors better find and map prostate cancer in the body. It will involve 6 patients with prostate cancer and compare the new scans to a current standard scan (68Ga-PSMA-11 PET). The goal …

This study is testing whether a medication called fezolinetant can safely reduce the frequency and severity of hot flashes in men with prostate cancer who are undergoing hormone-blocking therapy. Researchers will compare the drug to a placebo in 60 participants over 4 weeks to se…

This study is testing whether an 8-week learning program for prostate cancer patients and their spouses helps them cope better. Couples will either receive usual care or usual care plus the program, which includes weekly topics, a mobile app, and professional support. Researchers…

This study aims to understand how prostate cancer is diagnosed and treated in Algeria by tracking 2000 patients. Researchers will collect information about patients' backgrounds, symptoms, tests, treatments, and outcomes. The goal is to create a detailed picture of current care p…

This study aims to understand why some prostate cancer patients don't respond to a targeted radiation treatment called 177Lu-PSMA-RLT. Researchers will measure how much radiation reaches tumors after one treatment cycle to see if this measurement can predict which patients will u…