Laser zaps prostate tumors without major surgery
NCT ID NCT07339943
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new, less invasive way to treat intermediate-risk prostate cancer using a laser guided by micro-ultrasound. The goal is to see if the procedure is safe and can delay or avoid the need for more aggressive treatments like surgery or radiation. Seven men aged 40-80 with early-stage prostate cancer will be enrolled and followed for 6 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- laser ablation (heat therapy delivered via a diode laser system)
- What this could lead to
- If successful, this could offer a less invasive option for men with intermediate-risk prostate cancer, potentially delaying or avoiding the need for surgery or radiation.
- What could go wrong
- This is a very early, small study with only 7 participants, so results may not apply to everyone. The procedure may not fully eliminate the cancer or could cause side effects like pain or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 7 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Apr 2025
- Expected to finish
-
Dec 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 85 years
- Sex
-
Male participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men 40-80 years of age. * Histologically-proven intermediate-risk PCa (Gleason score 7, primary grade ≤ 4). * PCa clinical stage T1c or T2. * MRI/MicroUS site suspicious for cancer or cancer mapped to one prostate lobe. * Maximum dimension of MRI/MicroUS visible tumour ≤15mm. * Suspicious site on Prostate MRI/MicroUS must coincide with sector positive for cancer on biopsy. * Prostate specific antigen (PSA) level \< 15 ng/mL. * IPSS, ICIQ-UI-SF, IIEF-15 questionnaires completed prior to the procedure. * Life expectancy of greater than 10 years, based on co-morbidity not related to PCa. Exclusion Criteria: * Maximum dimension of MRI/MicroUS visible tumour \> 15 mm. * Patients medically unfit for focal therapy of the prostate. * Patients who are unwilling or unable to give informed consent. * Patients who have received androgen suppression therapy. * Patients who have received or are receiving chemotherapy for prostate carcinoma. * Patients previously treated with surgery to the prostate (traditional, endoscopic or minimally invasive) including HIFU, TUNA, RITA, microwave, cryotherapy or any curative treatment. * Patients who have undergone radiation therapy for PCa or to the pelvis. * Any condition or history of illness or surgery that, in the opinion of the Investigator, might confound the results of the study or pose additional risks to the patient (e.g. significant cardiovascular conditions or allergies). * Patients with a history of non-compliance with medical therapy and/or medical recommendations. * Patients who are unwilling or unable to complete the patient self-assessment questionnaires. * Chronic or acute prostatitis, neurogenic bladder, urinary tract infection, sphincter abnormalities, or any other symptom that prevents normal micturition. * Patients who have participated in a clinical study and/or received treatment with an investigational treatment and/or product within the past 90 days. * Patients with contraindication to MRI (i.e. pacemaker, hip prosthesis, severe claustrophobia, brain aneurysm clip, allergy to MRI contrast agent)
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Low and intermediate risk prostate cancer are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
University Health Network - Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 2M9, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Hidden bacteria in prostate tumors may shape how the immune system fights cancer
- Prostate tumors hide a Nerve-Fueled neighborhood, and scientists are mapping it
- A proactive care plan may help men with prostate cancer live better
- Can a simple blood test outsmart prostate cancer?
- A sharper eye on prostate cancer: could new imaging spare healthy tissue?
- Can a new drug combo tame resistant prostate cancer?