PROSTATE CANCER (ADENOCARCINOMA)

This early-stage study tests a new drug called ACE-232 in people with a hard-to-treat type of advanced prostate cancer that has stopped responding to standard therapies. The main goals are to check the drug's safety, find the right dose, and see early signs of whether it can help…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE1 • Sponsor: Acerand Therapeutics (Hong Kong) Limited • Aim: Disease control

Last updated May 26, 2026 02:29 UTC

New laser zaps prostate tumors without major surgery

This study tests a new, less invasive treatment for men with intermediate-risk prostate cancer. Doctors use micro-ultrasound to guide a laser that destroys the tumor, aiming to control the disease and delay or avoid the need for surgery or radiation. The study enrolls 7 men aged …

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: University Health Network, Toronto • Aim: Disease control

Last updated May 26, 2026 02:26 UTC

Could adding chemo to hormone therapy stop prostate cancer from spreading?

This study is for people with prostate cancer that has spread and is not responding as well as hoped to standard hormone therapy. Researchers want to see if adding a chemotherapy drug called docetaxel to the usual treatment can lower the chance of the cancer growing or spreading.…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE3 • Sponsor: Canadian Cancer Trials Group • Aim: Disease control

Last updated May 26, 2026 02:25 UTC

New prostate cancer combo aims to boost Radiation's punch

This study tests a new drug called aglatimagene besadenovec (given as an injection) along with valacyclovir in 45 men with intermediate-risk prostate cancer who are about to get radiation therapy. The main goal is to see where the drug goes in the body and how it affects the immu…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2 • Sponsor: Candel Therapeutics, Inc. • Aim: Disease control

Last updated May 26, 2026 02:22 UTC

Major trial tests best radiation strategy for prostate cancer

This study compares four radiation approaches for men with localized prostate cancer that hasn't spread. One group gets standard radiation, while three others get an extra radiation boost using different techniques. The goal is to see which method best prevents cancer from coming…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2, PHASE3 • Sponsor: Affidea Nu-med Center of Oncological DIagnostics and Therapy • Aim: Disease control

Last updated May 26, 2026 02:21 UTC

New adaptive radiation aims to spare bladder in prostate cancer patients

This study is testing a new type of radiation therapy that adapts to the patient's anatomy in real time. It is for men with localized prostate cancer who also have an enlarged prostate or urinary symptoms. The goal is to see if this approach can reduce side effects while still ef…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Sponsor: University of Zurich • Aim: Disease control

Last updated May 22, 2026 14:04 UTC

New drug combo aims to shrink prostate tumors before surgery

This early-phase trial tests whether giving two drugs (darolutamide and relugolix) before prostate cancer surgery is safe and practical for men with high-risk prostate cancer. About 30 adult men will receive the drug combination for a short time before their prostate is removed. …

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE1 • Sponsor: AdventHealth • Aim: Disease control

Last updated May 22, 2026 14:01 UTC

Radiation before surgery shows promise for aggressive prostate cancer

This study is for men with high-risk prostate cancer that has not spread. It tests whether giving a strong, targeted radiation treatment (high-dose brachytherapy) before robotic prostate surgery, followed by hormone therapy if needed, is safe and effective. About 29 participants …

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE1, PHASE2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control

Last updated May 22, 2026 13:50 UTC

New hope for Hard-to-Treat prostate cancer: experimental drug HLD-0915 enters human trials

This early-stage study tests an experimental drug called HLD-0915 in men with metastatic castration-resistant prostate cancer (mCRPC) whose cancer has worsened despite standard treatments. The study has two parts: first, finding a safe dose, then testing how well that dose works.…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE1, PHASE2 • Sponsor: Halda Therapeutics OpCo, Inc. • Aim: Disease control

Last updated May 20, 2026 11:58 UTC

Gut bacteria may unlock prostate cancer drug resistance

This study tests whether adding dexamethasone or metronidazole can make abiraterone work again for men with advanced prostate cancer that has stopped responding to treatment. About 58 men will receive one of these add-on drugs alongside their current therapy. The goal is to lower…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control

Last updated May 20, 2026 11:57 UTC

One and done? new prostate cancer radiation trial aims to cut treatment to a single session

This study tests whether a single, precise dose of radiation can safely control prostate cancer in men with intermediate or high-risk disease. About 58 participants will receive one targeted treatment session, along with standard hormone therapy. The goal is to see if this shorte…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Sponsor: University of Milano Bicocca • Aim: Disease control

Last updated May 18, 2026 12:13 UTC

Sharper radiation aims to zap prostate cancer with fewer side effects

This study tests a new way to give radiation for prostate cancer that adapts to your body shape each day. The goal is to safely give a higher dose to the cancer while protecting nearby organs. About 80 adults with intermediate- or high-risk prostate cancer will receive 5 treatmen…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: Fox Chase Cancer Center • Aim: Disease control

Last updated May 18, 2026 12:07 UTC

New hope for Hard-to-Treat prostate cancer: drug combo trial launches

This study tests whether the drug talazoparib, given alone or with enzalutamide, can slow cancer growth in men with a specific type of advanced prostate cancer (metastatic castration-resistant) that has certain gene mutations (HRR) and has already progressed after treatment with …

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2 • Sponsor: Prostate Cancer Clinical Trials Consortium • Aim: Disease control

Last updated May 18, 2026 12:00 UTC

New hope for hard-to-treat prostate cancer: drug duo enters trial

This study tests two drugs, SKB264 and KL-A167, together in people with aggressive or neuroendocrine prostate cancer that has stopped responding to hormone therapy. The goal is to see if the combination can shrink tumors or slow the disease. About 28 adults who have already tried…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2 • Sponsor: Tianjin Medical University Second Hospital • Aim: Disease control

Last updated May 15, 2026 11:54 UTC

New imaging method could sharpen prostate cancer diagnosis

This study tests two new imaging probes (68Ga-G21 and 68Ga-G23) that target a protein found on most prostate cancer cells. The goal is to see if they can improve diagnosis and staging compared to current PSMA PET scans. About 6 adults with prostate cancer will receive the probes …

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE1, PHASE2 • Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Diagnosis

Last updated May 26, 2026 02:26 UTC

New laser microscope could help surgeons save nerves during prostate cancer surgery

This study tests a new method called LaserSAFE that uses a special microscope to scan the removed prostate during surgery. The goal is to see if it can quickly find cancer at the edges of the prostate, helping surgeons decide whether to save or remove nearby nerves. About 693 men…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: University College, London • Aim: Diagnosis

Last updated May 26, 2026 02:23 UTC

New PET tracer takes on MRI in prostate cancer showdown

This study compares a new PET imaging agent (68Ga-P16-093) with standard MRI for detecting prostate cancer in 50 newly diagnosed patients who have not yet received treatment. Participants will receive both scans before surgery, and results will be checked against the removed pros…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE1, PHASE2 • Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Diagnosis

Last updated May 20, 2026 11:54 UTC

New PET scan could outshine MRI for prostate cancer detection

This study aims to see if a special PET scan (68Ga-PSMA-11) is better than standard MRI at finding prostate tumors in men who have just been diagnosed and haven't had treatment yet. About 100 participants will get both scans before their prostate removal surgery, and the results …

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2, PHASE3 • Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Diagnosis

Last updated May 19, 2026 12:00 UTC

New scan spots hidden prostate cancer when PSA is nearly undetectable

Symptom relief Recruiting now

This study looks at whether a special PET scan (flotufolastat F 18) can find prostate cancer that has come back in men with very low PSA levels (0.20 ng/mL or less) after their prostate was removed. About 50 men who had surgery for prostate cancer and now have a small rise in PSA…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Sponsor: Massachusetts General Hospital • Aim: Diagnosis

Last updated May 14, 2026 12:06 UTC

Couples tackle prostate cancer together in new study

This study helps prostate cancer patients and their spouses cope better by learning and supporting each other. Over 8 weeks, couples use a mobile app and get professional support to improve physical symptoms, emotional health, and resilience. About 60 couples will join, with half…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: National Taipei University of Nursing and Health Sciences • Aim: Symptom relief

Last updated May 26, 2026 02:28 UTC

New hope for Men's hot flashes: drug targets sweaty side effect of prostate cancer treatment

Symptom relief Recruiting now

This study tests a drug called fezolinetant to see if it can reduce hot flashes in men with prostate cancer who are on hormone therapy (ADT). About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency, severity, and any liver…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: PHASE2 • Sponsor: Shehzad Basaria, M.D. • Aim: Symptom relief

Last updated May 26, 2026 02:25 UTC

Prostate cancer patients may get fewer side effects with smarter radiation dosing

Symptom relief Recruiting now

This study tests whether giving a lower radiation dose to healthy parts of the prostate, while keeping a high dose only to visible tumors, can reduce bowel and urinary side effects in men with low- or intermediate-risk prostate cancer. About 54 men will receive two MRI-guided rad…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: The Netherlands Cancer Institute • Aim: Symptom relief

Last updated May 26, 2026 02:23 UTC

PSA after prostate surgery: a crystal ball for cancer?

This study follows 500 men who had their prostate removed for cancer. Researchers check PSA levels soon after surgery to see if they can predict if the cancer will come back or spread. No new treatments are given—just standard care and monitoring.

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Sponsor: Lithuanian University of Health Sciences • Aim: Knowledge-focused

Last updated May 26, 2026 02:21 UTC

New scan combo aims to catch returning prostate cancer earlier

This study looks at whether adding a PSMA PET scan to the usual MRI scan can better find prostate cancer that has come back after focal therapy (a treatment that targets only the tumor). About 62 men who have had focal therapy will get both scans. The goal is to see if the PSMA P…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: University of Chicago • Aim: Knowledge-focused

Last updated May 22, 2026 14:02 UTC

New study aims to predict prostate cancer treatment success early

This study looks at whether a special scan can predict if men with advanced prostate cancer will respond to a targeted radiation treatment. About 110 men will get the treatment and have scans to measure the radiation dose to their tumors. The goal is to see if the dose can tell e…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Sponsor: Jules Bordet Institute • Aim: Knowledge-focused

Last updated May 22, 2026 13:54 UTC

What do men think about breast side effects? new study seeks answers

This study talks to men with prostate cancer to learn how they feel about breast-related side effects, like breast growth, from their treatment. Researchers will interview 24 men to understand their concerns and what trade-offs they are willing to make. The goal is to help doctor…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: St Vincent's Hospital, Sydney • Aim: Knowledge-focused

Last updated May 22, 2026 13:52 UTC

3D model may help surgeons better remove spread prostate cancer

This study tests whether a 3D virtual model, created from a special scan, can help surgeons more precisely remove prostate cancer that has spread to nearby lymph nodes. About 100 men with prostate cancer scheduled for surgery will take part. The goal is to see if the model improv…

Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)

Phase: NA • Sponsor: Martini-Klinik am UKE GmbH • Aim: Knowledge-focused

Last updated May 20, 2026 11:55 UTC

Algerian prostate cancer study seeks 2,000 patients to map disease patterns