PRIMARY ALDOSTERONISM

This study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a specific type of high blood pressure called primary aldosteronism. About 122 adults with this condition will be randomly assigned to one of the two treatments. The goa…

This study compares a new, less invasive procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to standard surgery (adrenalectomy) for treating left-sided primary aldosteronism, a condition where the adrenal gland makes too much aldosterone. About 60 adu…

This study tests a new medicine called HRS-1780 in 60 adults with primary aldosteronism, a condition where the adrenal glands make too much of a hormone that raises blood pressure. Participants will receive either the drug or a placebo to see if it safely lowers blood pressure be…

This study looks at whether measuring a hormone called renin can help doctors choose the best dose of a blood pressure drug (MRA) for people with primary aldosteronism, a condition that causes hard-to-control high blood pressure. About 58 adults with a new diagnosis will be split…

This study looks at whether a procedure called superselective adrenal arterial embolization can improve blood vessel function in people with primary aldosteronism, a condition where the adrenal glands produce too much of the hormone aldosterone, leading to high blood pressure. Th…

This study tests whether a special PET/CT scan (68Ga-Pentixafor) is as good as the standard, more invasive adrenal vein sampling for diagnosing a specific type of high blood pressure caused by a hormone imbalance (primary aldosteronism with cortisol excess). About 178 adults with…

This study looks at whether a new steroid-based blood test can more accurately identify a curable form of high blood pressure called primary aldosteronism. About 406 adults with high blood pressure will have their blood tested while continuing their usual medications. The goal is…

This study compares three different ways of performing a blood test (adrenal vein sampling) to find the best method for diagnosing primary aldosteronism, a condition where the adrenal glands make too much of the hormone aldosterone, causing high blood pressure. About 456 adults a…

This study aims to discover new biological markers in blood, urine, and adrenal tissue that could help doctors diagnose primary aldosteronism earlier. Primary aldosteronism is a common but often missed cause of high blood pressure that can lead to heart and kidney problems. Resea…

This study follows 5,000 people with primary aldosteronism, a common but often missed cause of high blood pressure, to see how different treatments affect heart and kidney health over 5 years. Researchers will compare surgery, medication, and other therapies to find which works b…

This study follows 1,000 adults with primary aldosteronism (a hormone disorder that causes high blood pressure) to see how often they develop memory or thinking problems. Participants take regular cognitive tests and health check-ups for up to 5 years. The goal is to understand t…

This study looks at how often the adrenal glands stop working properly after surgery in patients with primary aldosteronism (a cause of high blood pressure) who may also have extra cortisol production. About 521 adults who had one adrenal gland removed will be followed to see if …

This study looks at whether taking a single 1 mg dose of dexamethasone at bedtime can make screening for primary aldosteronism more accurate in people already taking blood pressure medications. Primary aldosteronism is a condition where the adrenal gland makes too much aldosteron…