PARKINSONS DISEASE (PD)

This large Phase 3 trial is testing whether two common drugs, telmisartan and terazosin, can slow the progression of Parkinson's disease. 1,200 participants will receive either a drug or a placebo for up to 36 months. The study uses a flexible design that can add new treatments o…

This early-phase study tests whether a supplement called gamma-glutamylcysteine (GGC) can increase levels of the brain's master antioxidant, glutathione, in people with early Parkinson's disease. Researchers will measure changes in brain chemistry, motor skills, thinking abilitie…

This study tests a treatment called bemdaneprocel, which involves transplanting dopamine-producing nerve cells into the brains of people with Parkinson's disease. The goal is to reduce daily 'OFF' time—when symptoms return—and increase 'ON' time without uncontrolled movements. Ab…

This study tests a new type of exercise for people with early-stage Parkinson's disease. Instead of just playing a video game on a screen, participants will use real physical objects along with the game to practice hand movements. The goal is to see if this 'phygital' approach im…

This study tests whether a dietitian-designed diet can improve constipation in people with Parkinson's disease. Fifty-four adults with Parkinson's and constipation will follow a personalized diet plan for 3 months. Researchers will track bowel movements, gut bacteria, and diet qu…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve motor function and reduce fatigue in people with Parkinson's disease. Researchers will apply mild electrical current to the movement-control area of the brain over multiple sessions. The t…

This study uses advanced MRI scans to look at a newly discovered brain network, called SCAN, in people with Parkinson's disease and healthy volunteers. Researchers want to see if this network is linked to the movement problems in Parkinson's. The goal is to find a specific brain …

This study looks at why swallowing problems happen in Parkinson's disease, a common issue that can lead to serious health risks like pneumonia. Researchers will study 100 people with Parkinson's using swallowing tests, brain scans, and blood tests to understand the causes and how…

This study tests whether a mild electrical pulse to the ear—called transcutaneous auricular vagus nerve stimulation—can improve decision-making and problem-solving. Researchers will compare results in healthy adults, people with mild cognitive impairment, and those with Parkinson…

This study looks at a gene called csgA found in gut bacteria. Researchers want to see how common it is and how it changes over time in 200 people with Parkinson's disease who have or had gut problems. The goal is to learn more about the link between gut bacteria and Parkinson's, …