PARKINSONS DISEASE (PD)

This early-phase study tests whether a supplement called gamma-glutamylcysteine (GGC) can increase levels of the brain's master antioxidant, glutathione, in people with early Parkinson's disease. Researchers will measure changes in brain chemistry, motor skills, thinking abilitie…

This study tests a treatment called bemdaneprocel, which involves transplanting dopamine-producing nerve cells into the brains of people with Parkinson's disease. The goal is to reduce daily 'OFF' time—when symptoms return—and increase 'ON' time without uncontrolled movements. Ab…

This large clinical trial is testing several potential treatments at the same time to see if any can slow down Parkinson's disease. About 1,200 people with Parkinson's will take either an experimental drug or a placebo, and most visits can be done from home. The goal is to find a…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve motor function and reduce fatigue in people with Parkinson's disease. Researchers will apply mild electrical current to the movement-control area of the brain over multiple sessions. The t…

This study tests whether a dietitian-designed diet can improve constipation in people with Parkinson's disease. Fifty-four adults with Parkinson's and constipation will follow a personalized diet plan for 3 months. Researchers will track bowel movements, gut bacteria, and diet qu…

This study tests a new approach to hand therapy for people with early-stage Parkinson's disease. Instead of just using a video game on a screen, participants will play games that involve touching and moving real objects. The goal is to see if this 'phygital' method improves hand …

This study uses advanced brain scans to see if a newly discovered brain network, called SCAN, is affected in people with Parkinson's disease. Researchers will compare brain scans of 120 participants (some with Parkinson's, some healthy) to understand how this network connects to …

This study looks at why swallowing problems happen in Parkinson's disease. Researchers will study 100 people with Parkinson's using swallowing tests, brain scans, and blood tests. The goal is to understand the causes and find ways to predict and treat these problems, which can le…

This study tests whether a mild electrical pulse to the ear—called transcutaneous auricular vagus nerve stimulation—can improve decision-making and problem-solving. Researchers will compare results in healthy adults, people with mild cognitive impairment, and those with Parkinson…

This study looks at a gene called csgA found in gut bacteria. Researchers want to see how common it is and how it changes over time in 200 people with Parkinson's disease who have or had gut problems. The goal is to learn more about the link between gut bacteria and Parkinson's, …