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Brain cell transplant trial aims to give Parkinson's patients more good hours each day

NCT ID NCT06944522

Disease control Sponsor: BlueRock Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This study tests a treatment called bemdaneprocel, which involves transplanting dopamine-producing nerve cells into the brains of people with Parkinson's disease. The goal is to reduce daily 'OFF' time—when symptoms return—and increase 'ON' time without uncontrolled movements. About 102 adults aged 45 to 75 with moderate Parkinson's will receive either the cell therapy or a sham surgery, and be followed for safety and symptom improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 102 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Mar 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of clinically established PD as defined by the International Parkinson and Movement Disorders Society * Individual of any sex ≥45 to ≤75 years of age at informed consent * Robust and clear response to DA therapy as defined by MDS-UPDRS Part III * ≥4 and \<12 years from time of PD diagnosis at informed consent * Must demonstrate responsiveness to levodopa therapy * Receiving medical therapy for the treatment of PD symptoms * ≥2.5 hours of daily OFF-time * Vaccinated per current national guidelines or local practice for patients with altered immunocompetence Exclusion Criteria: * PD presenting with recurrent falls * Diagnosis of primary mitochondrial disorder, epilepsy, stroke, multiple sclerosis, or clinical features suggestive of a neurodegenerative disease other than PD, including multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, or Lewy body dementia * Any current or relevant previous history of serious, severe, or unstable physical, neurological, or psychiatric illness that may interfere with study participation, participant's safety, or assessment of endpoints per investigator's judgment * History of gene therapy or cell therapy * Prior treatment with intrajejunal or subcutaneous infusion therapies for PD * Prior surgical or radiation therapy to the brain, including deep brain stimulation (DBS) and lesion therapy, or prior history of intradural spinal cord surgery * Contraindication to surgery, general anesthesia, cell therapy, immunosuppression, or other required drugs, or anything that prevents use of PET or MRI * Any active infection (including but not limited to HIV, HCV, HBV, CMV, syphilis, or tuberculosis) or condition that, in the opinion of the investigator could put the participant at significant risk from immunosuppression or impact the participant's ability to perform study assessments * Current or previously active malignant disease within the past 5 years * Chronic immunosuppressive therapy * Receipt of another investigational therapy within 5 half-lives of the active treatment * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinsons disease (PD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    43 sites in 3 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Banner Sun Health Research Institute

    RECRUITING

    Sun City, Arizona, 85351, United States

    Contact Email: •••••@•••••

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact Email: •••••@•••••

  • CHUM - Centre hospitalier de l'Université de Montréal

    RECRUITING

    Montreal, Quebec, H2X 0C1, Canada

    Contact Email: •••••@•••••

  • Duke Neurological Disorders Clinic

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Email: •••••@•••••

  • EvergreenHealth - Research Department

    RECRUITING

    Kirkland, Washington, 98034, United States

    Contact Email: •••••@•••••

  • Gold Coast Hospital & Health Service

    RECRUITING

    Southport, Queensland, 4215, Australia

    Contact Email: •••••@•••••

  • Johns Hopkins Hospital - Neurology

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact Email: •••••@•••••

  • Mayo Clinic Jacksonville - Neurology

    RECRUITING

    Jacksonville, Florida, 32224, United States

    Contact Email: •••••@•••••

  • Mayo Clinic Scottsdale - Neurology

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Email: •••••@•••••

  • MedStar Georgetown University Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

    Contact Email: •••••@•••••

  • Medical University of South Carolina, Movement Disorders Dept.

    RECRUITING

    Charleston, South Carolina, 29425, United States

    Contact Email: •••••@•••••

  • Michigan Clinical Research Unit - Neurology

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Email: •••••@•••••

  • Monash Medical Centre

    RECRUITING

    Clayton, Victoria, 3168, Australia

    Contact Email: •••••@•••••

  • Mount Sinai West - Neurology

    RECRUITING

    New York, New York, 10019, United States

    Contact Email: •••••@•••••

  • NeuRA (Neuroscience Research Australia)

    RECRUITING

    Randwick, New South Wales, 2031, Australia

    Contact Email: •••••@•••••

  • New York Presbyterian/Weill Cornell Medical Center

    RECRUITING

    New York, New York, 10065, United States

    Contact Email: •••••@•••••

  • OHSU Neurology Clinic, South Waterfront

    RECRUITING

    Portland, Oregon, 97239, United States

    Contact Email: •••••@•••••

  • Parkinson's Disease and Movement Disorders Center at Northwestern Memorial Hospital

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

  • Princess Alexandra Hospital

    RECRUITING

    Woolloongabba, Queensland, 4102, Australia

    Contact Email: •••••@•••••

  • Quest Research Institute

    RECRUITING

    Farmington Hills, Michigan, 48334, United States

    Contact Email: •••••@•••••

  • Rhode Island Hospital - Neurology

    RECRUITING

    Providence, Rhode Island, 02903, United States

    Contact Email: •••••@•••••

  • Rush University Medical Center - Neurology

    RECRUITING

    Chicago, Illinois, 60612, United States

    Contact Email: •••••@•••••

  • Stanford Neuroscience Health Center

    RECRUITING

    Palo Alto, California, 94304, United States

    Contact Email: •••••@•••••

  • The Alfred Hospital

    RECRUITING

    Melbourne, Victoria, 3004, Australia

    Contact Email: •••••@•••••

  • The Royal Melbourne Hospital

    RECRUITING

    Parkville, Victoria, 3050, Australia

    Contact Email: •••••@•••••

  • The University of British Columbia

    RECRUITING

    Vancouver, British Columbia, V6T 1Z3, Canada

    Contact Email: •••••@•••••

  • Tufts Medical Center - Neurology

    RECRUITING

    Boston, Massachusetts, 02111, United States

    Contact Email: •••••@•••••

  • UBMD Neurology

    RECRUITING

    Buffalo, New York, 14221, United States

    Contact Email: •••••@•••••

  • UCI Medical Center - Neurology

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

  • UCLA NeuroTranslational Research Center

    RECRUITING

    Los Angeles, California, 90095, United States

    Contact Email: •••••@•••••

  • USF Parkinson's Disease and Movement Disorders Center

    RECRUITING

    Tampa, Florida, 33613, United States

    Contact Email: •••••@•••••

  • UTHealth Houston Neurosciences - Texas Medical Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

  • University Health Network - Toronto Western Hospital

    RECRUITING

    Toronto, Ontario, M5T 2S8, Canada

    Contact Email: •••••@•••••

  • University of Arkansas for Medical Sciences

    RECRUITING

    Little Rock, Arkansas, 72205, United States

    Contact Email: •••••@•••••

  • University of Colorado Hospital - Neurology Clinic

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Email: •••••@•••••

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160-8500, United States

    Contact Email: •••••@•••••

  • University of Louisville Hospital

    RECRUITING

    Louisville, Kentucky, 40202, United States

    Contact Email: •••••@•••••

  • University of Miami Health System - Neurology

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Email: •••••@•••••

  • University of Michigan Clinical Research Unit - Neurology

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Email: •••••@•••••

  • University of Toledo Medical Center

    RECRUITING

    Toledo, Ohio, 43614, United States

    Contact Email: •••••@•••••

  • University of Vermont Medical Center

    RECRUITING

    Burlington, Vermont, 05401, United States

    Contact Email: •••••@•••••

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

    Contact Email: •••••@•••••

  • Virginia Commonwealth University

    RECRUITING

    Richmond, Virginia, 23284, United States

    Contact Email: •••••@•••••

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