PANCREATIC NEOPLASM

This early-phase trial tests whether combining two targeted drugs—sunitinib malate and lutetium Lu 177 dotatate (Lutathera)—is safe and effective for people with advanced pancreatic neuroendocrine tumors. The study enrolls 24 adults whose tumors have spread or cannot be removed. …

This study tests a precise form of radiation called carbon ion radiotherapy in 33 frail adults with pancreatic cancer who cannot have surgery or standard chemotherapy. The goal is to see if this treatment can help control the tumor and improve survival with fewer side effects. Pa…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare cancers will receive the drug combinat…

This study tests a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pancreatic cysts that have a high risk of turning into cancer. The goal is to shrink these cysts by at least half using heat energy delivered through a thin needle, avoidin…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This study tests a new drug called LY4170156 in people with advanced solid tumors, such as ovarian, lung, and breast cancers. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has two parts: first to find the safest dose, then to see how w…

This study looks at whether adding an MRI scan to the usual CT scan helps doctors choose the best treatment for people with pancreatic cancer. About 200 patients who are initially thought to be candidates for surgery will be randomly assigned to get either a CT scan alone or a CT…

This study tests if giving the drug lanreotide before pancreatic surgery can prevent a common complication called a pancreatic fistula, where digestive fluids leak from the pancreas. About 274 people with pancreatic cancer or pre-cancerous lesions will be randomly assigned to rec…

This study tests if a nerve block using long-lasting numbing medicine works as well as an epidural for pain after pancreatic surgery. About 78 adults having this surgery will be randomly assigned to one of the two methods. The goal is to see if the nerve block provides similar pa…

This study reviews medical records of 500 adults who had pancreas surgery to find out why some develop delayed gastric emptying (slow stomach emptying). The goal is to identify risk factors like surgery type or feeding tube use, so doctors can better manage this complication and …

This study is collecting data from 3500 people who had pancreatic surgery to understand how the operation affects their blood sugar control, digestion, and overall quality of life. Researchers will compare different surgical methods and how much pancreas remains after surgery. Th…

This study explores whether a special 3D MRI scan (called MR elastography) can measure the stiffness of pancreatic tumors and surrounding scar tissue. Researchers aim to see if these measurements help predict how the cancer will respond to chemotherapy. The study involves 200 adu…