Overweight/obesity

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This 52-week trial tests whether combining a structured lifestyle program with a mushroom-based supplement and the drug bupropion helps overweight adults lose weight and lower cardiometabolic risk. About 250 adults aged 18 to 55 with a BMI between 25 and 35 will be randomly assig…

This trial tests an experimental oral drug called TQF3250, which mimics a natural hormone that helps control appetite and blood sugar. Researchers will give the drug or a placebo to 80 overweight or obese adults who have not had success with diet and exercise alone. The main goal…

This trial tests whether an online weight loss program with specific daily goals, called the 30-30-30 plan, helps people lose more weight than a standard online program. The plan asks participants to eat at least 30 grams of protein per meal, 30 grams of fiber per day, and get 30…

This early-stage trial is testing an investigational injection called MWN110 in healthy volunteers and in people who are overweight or obese. The study aims to see if the injection is safe and tolerable, and how it affects body weight and composition. Participants receive either …

This phase 3 trial is testing whether an investigational injection called MWN109 can help non-diabetic adults with overweight or obesity lose weight. About 760 participants will receive either MWN109 or a placebo once a week for a year. The main goals are to see how much weight p…

This study tests whether adding cognitive behavioral therapy for insomnia (CBTI) to a flexible time-restricted eating plan helps adults with overweight or obesity and chronic insomnia lose more weight. Participants will either follow the eating plan alone or combine it with CBTI,…

This trial tests whether taking antioxidant-rich supplements for 12 weeks can improve skin and blood carotenoid levels, antioxidant status, and cardiometabolic health in overweight and obese adults aged 21-70. Participants maintain their usual diet while adding either LifePak Ele…

This study investigates whether a supervised, adapted physical activity program can improve how the body burns fat during walking in women with overweight or obesity, both with and without polycystic ovary syndrome (PCOS). Researchers will compare changes in fat oxidation and oth…

This study tests a new injectable drug called SRSD384 in 78 overweight or obese adults. In the first part, participants receive a single dose of SRSD384 alone. In the second part, they receive SRSD384 combined with another weight-loss drug, tirzepatide. The main goal is to check …

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This study tests whether adding exercise-focused lifestyle coaching to a personalized diet plan improves health in 435 overweight or obese adults with metabolic syndrome. Participants will either follow a diet plan alone or a diet plan plus an intelligent lifestyle program that t…

This study tests whether adding metformin (a diabetes drug) to the standard psoriasis treatment secukinumab works better than secukinumab alone for overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. About 186 participants will be randomly assigned to r…

This study tests whether a family-based weight management program can slow the start of puberty in girls aged 6.5 to 8 years who have overweight or obesity. Half of the 240 girls will join a 20-session program focused on healthy eating and activity, while the other half receive u…

This study tests whether replacing some regular gym classes with specialized physical education courses can prevent common health issues like nearsightedness, overweight, anxiety, and depression in junior high students. Two hundred students will be randomly assigned to either the…

This study tests a smartphone app that combines acceptance and commitment therapy, a pedometer, and health education to help overweight or obese adults reduce weight-related shame and lose weight. Sixty participants will be randomly assigned to use the app or receive standard hea…

This study tests whether a 10-week camp program can help children and teens (ages 7-14) reduce binge eating. Some parents will also receive special training to see if it adds extra benefit. Researchers will follow participants for up to 5 years to track lasting effects.

This study looks at how a 12-week aerobic exercise program affects brain activity and stress hormones in veterans with overweight or obesity. Researchers will use brain scans and stress tests to see if exercise changes how participants react to pictures of high-calorie foods and …

This observational pilot study explores whether adults with obesity in England, France, and Germany can participate in research entirely from home. Participants will authorize access to their medical records and complete an online questionnaire about their health, quality of life…

This phase 1 study investigates whether ZT002 (zovaglutide), an experimental injectable drug given every two weeks, affects the heart's electrical activity in overweight or obese adults. Researchers compare changes in the QT interval—a measure of heart rhythm—between those receiv…

This study explores whether taking a dietary fibre supplement during a 10-day fast can improve gut health and metabolism more than fasting alone. Overweight adults (BMI 25 or higher) will fast at a clinic and then either receive a resistant starch fibre or a placebo. Researchers …

This study looks at whether one session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight. Sixty women will receive either real or fake stimulation while their heart activity…

This study will look at medical records of 1700 adults with obesity who took tirzepatide along with lifestyle coaching at several Dutch clinics. Researchers want to see how much weight people actually lose after six months and how doctors prescribe the medication in daily practic…