OCD

This study tests whether a gentle nerve-stimulation device (tVNS) can make exposure therapy work better for people with OCD. About 56 adults with moderate to severe OCD will receive tVNS during therapy sessions. The goal is to see if this combination reduces obsessive thoughts an…

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study tests a gentle, non-invasive brain stimulation method to reduce OCD symptoms. Researchers use EEG to guide electrical currents to a key brain region, aiming for rapid improvement within five days that lasts up to three months. The trial enrolls 90 adults with OCD and h…

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study tests a new 5-day accelerated version of TMS, a brain stimulation treatment already approved for depression and OCD. Researchers want to see if this faster approach can quickly improve symptoms and use brain scans to predict who benefits most. 500 adults with depressio…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. About 240 adults aged 18-55 who struggle with emotion regulation will be …

This study aims to find clear differences between tics and compulsions using brain wave recordings and smartwatch movement sensors. Researchers will study 50 people with OCD or Tourette syndrome, both in the lab and at home. The goal is to improve diagnosis and guide better treat…

This study will review the medical records of about 12,000 people who received mental health treatments for depression, OCD, or anxiety. Researchers want to compare how well two treatments—NeuroStar TMS and esketamine—work in real-world settings by looking at changes in symptom s…

This study looks at brain activity and thinking skills in 100 people with OCD to find clues about why some don't respond to standard treatments. By comparing their brain scans during memory and attention tasks, researchers hope to create personalized care plans. Participants must…

This study looks at how natural hormone changes during the menstrual cycle might affect brain areas involved in fear and anxiety. Researchers will give women with OCD a type of therapy called exposure and response prevention at different times in their cycle. The goal is to see i…