OBSTRUCTIVE SLEEP APNEA (OSA)

This study tests whether a program that includes remote monitoring, couple therapy, and peer support can help African American patients with sleep apnea use their CPAP machine more consistently. The goal is to improve sleep and quality of life for both the patient and their bed p…

This study tests an investigational drug called GZR18 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss. Participants wil…

This study tests an injectable drug called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 weeks. Participa…

This study will check if a special smart mattress can accurately detect obstructive sleep apnea (OSA) and other sleep problems compared to the standard sleep lab test (polysomnography). About 500 people will use the mattress during their sleep study. If it works well, it could of…

This study will see if a simple questionnaire given at the dentist can identify children ages 8-13 who are at risk for sleep-disordered breathing (including sleep apnea). Kids will be grouped as low- or high-risk based on the questionnaire, then wear a home sleep monitor to check…

This study tests whether myofunctional therapy—special exercises for the tongue, face, and breathing muscles—can improve sleep in children aged 6 to 12 with obstructive sleep apnea. Half of the 174 children will receive the therapy plus standard care, while the other half gets st…

This study tests a special mouthpiece that slowly moves the lower jaw forward during sleep to help people with mild-to-moderate obstructive sleep apnea breathe easier. Unlike standard devices that lock the jaw in one fixed position, this one adjusts gradually to reduce muscle and…

This study looks at whether giving people with sleep apnea access to their nightly oxygen levels helps them stay engaged with their mouthpiece therapy. About 120 adults with mild-to-moderate sleep apnea (or severe cases who can't use CPAP) will either get standard care or see the…

This study looks at whether a combination of non-opioid pain medicines works as well as fentanyl for children aged 5-10 with mild to moderate sleep apnea who are having their tonsils removed. The goal is to control pain effectively while reducing breathing problems and other side…

This study looks at people who have both sleep apnea and chronic insomnia. Everyone gets a CPAP machine, but half also start a digital insomnia program right away. The goal is to see if treating insomnia early helps them use CPAP more and improves their health. 120 adults aged 45…

This study tests whether a high-flow nasal cannula (HFNC) is a comfortable and effective alternative to CPAP for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the two devices at home for 3 months. Researchers will measur…

This study tests whether wearing a smartwatch and seeing its data can help people with obstructive sleep apnea use their CPAP machine more regularly. About 80 adults who are new to CPAP will be split into two groups: one can see their wearable data anytime, the other cannot until…

This study tests a 4-month personalized digital program (PASS) to help people with obstructive sleep apnea start and stick with positive airway pressure (PAP) therapy. Sixty adults who are newly diagnosed, overweight, and inactive will be randomly assigned to either the PASS prog…

This study will check if people with more severe sleep apnea also have higher blood pressure in their lungs. About 55 adults with sleep apnea will have their heart and lungs checked using ultrasound. No new treatments are tested—the goal is simply to understand the link between t…

This study looks at how brief periods of low oxygen (like those in sleep apnea) change the activity of certain immune cells called neutrophils. Researchers will collect blood from 120 people—some with moderate-to-severe sleep apnea and some without—to measure how these cells form…

This study tests a new software tool called Pressure Match that helps doctors choose the right CPAP pressure settings for people newly diagnosed with obstructive sleep apnea (OSA). The tool uses data from thousands of patients to give personalized pressure recommendations, aiming…

This study looks at how opioids change breathing during sleep in healthy volunteers and people with obstructive sleep apnea. Researchers will give participants morphine or a placebo and measure their breathing. The goal is to understand the risks, not to test a new treatment.

This study looks at whether a non-invasive lung function test called impulse oscillometry (IOS) can predict the correct pressure settings for sleep apnea therapy. About 92 adults with moderate-to-severe obstructive sleep apnea will take the test during the day and then have their…