OBSESSIVE COMPULSIVE DISORDER (OCD)

This study tests whether a lifestyle program can help people with obsessive-compulsive disorder (OCD) become more active and lower their risk for heart disease and diabetes. Researchers will enroll 108 adults with OCD who are not very active. Participants will either receive the …

This study tests whether deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) who have not gotten better with medication or therapy. DBS uses a device implanted in the brain to send electrical pulses to areas linked to mood and anxiety. The…

This study tests whether acceptance and commitment therapy (ACT), a form of talk therapy, can help adults with religiously focused obsessive-compulsive disorder (OCD). Ten participants will receive ACT and report changes in their symptoms. The goal is to see if this therapy is a …

This study tests two ways to help adults with obsessive-compulsive disorder (OCD) find and keep jobs. All 40 participants will receive up to 12 sessions of a proven therapy called exposure and response prevention. Half will also get extra job support, while the other half receive…

This study tests a stepped care model for treating anxiety in children and teens ages 7-17. It starts with a low-cost, parent-focused therapy and offers more intensive treatment only if needed. The goal is to make effective care easier to access and more affordable for families.

This study tests a new type of brain stimulation called Temporal Interference (TI) to see if it can reduce obsessive-compulsive symptoms in people with OCD. Researchers will use MRI and EEG scans to understand how the stimulation affects the brain. The trial involves 18 adults wi…

This study tests a new way to treat obsessive-compulsive disorder (OCD) using a type of brain stimulation called rTMS. Twenty adults with OCD will receive six sessions of rTMS each day for five days, targeting a specific brain area. The goal is to see if this treatment reduces OC…

This study tests whether a non-invasive magnetic brain stimulation technique (deep TMS) can reduce obsessive-compulsive disorder (OCD) symptoms. 96 adults with OCD will be randomly assigned to receive real or sham (fake) stimulation over 6 weeks. Researchers will also use brain s…

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About 160 veterans, half of whom also have PTSD, will receive either ERP or a cont…

This early-stage study is testing whether low-intensity focused ultrasound can safely target specific brain areas linked to obsessive-compulsive disorder (OCD). Ten adults with chronic OCD will receive single sessions of ultrasound to up to three brain targets. The main goal is t…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study is looking for genetic markers that may predict which children and youth (ages 6-24) with depression, anxiety, or OCD will experience behavioral activation—a side effect of SSRI antidepressants like Prozac or Zoloft. Researchers will compare the DNA of 160 participants…

This study looks at how the brains of people with Obsessive-Compulsive Disorder (OCD) process fear and safety signals. Researchers will use brain scans and mild electrical stimulation to see if they can improve the brain's ability to unlearn fear. The goal is to better understand…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…