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Could zapping the brain ease OCD? new trial begins

NCT ID NCT07113652

Symptom relief Sponsor: Shanghai Mental Health Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a device that uses gentle electrical fields to stimulate brain areas linked to OCD. 18 adults with moderate-to-severe OCD will receive either real or sham stimulation for 7 days. Researchers will measure symptom changes and use brain scans to understand how it works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temporal Interference (TI) stimulation device (nerviox-1000)
What this could lead to
If it works, this could point toward a new, non-invasive treatment option for obsessive-compulsive disorder that may help reduce symptoms.
What could go wrong
This is a very small, early study with only 18 people, so results may not apply widely. The device is experimental, and it is unknown if it will provide meaningful symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-50 years old * Diagnosis of OCD per DSM-5 * Y-BOCS score ≥20 * Have a documented history of at least two adequate trials of selective serotonin reuptake inhibitors (SSRIs). If currently receiving SSRI treatment, the dosage must be stable for at least 8 weeks prior to enrollment * With at least 9 years of education Exclusion Criteria: * Any DSM-5 diagnosis other than OCD (except OCPD) * OCD symptoms too severe to complete assessments * Received electroconvulsive therapy (ECT) within the past 6 months * Received other forms of neuromodulation within the past 2 months（see Item 3 for ECT） * Severe medical illness or seizure risk (e.g., cardiovascular, respiratory conditions) * Neurological disorders or history of brain injury/surgery * MRI-incompatible implants (e.g., pacemaker, stents, cochlear implants). * Current suicidal risk per investigator judgment * Pregnant or planning pregnancy during the study * Started structured OCD psychotherapy within 3 months, with expected change during treatment

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive compulsive disorder OCD

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai Mental Health Center

    RECRUITING

    Shanghai, Shanghai Municipality, 200030, China

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