NON-ALCOHOLIC STEATOHEPATITIS

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG) can help people with obesity and a serious liver condition called MASH. ESG reduces stomach size by about 70% using an endoscope, leading to significant weight loss. Researchers wi…

This study looks at how the liver responds to food and a drug called semaglutide in people with non-alcoholic fatty liver disease (NAFLD). About 84 adults, including healthy volunteers, will take part. Researchers will check if semaglutide can reduce liver fat and damage over 30 …

This study is testing whether a special ultrasound done during an endoscopy (EUS-SWE) can accurately detect liver scarring in people with obesity and suspected fatty liver disease. The procedure adds only 2-3 minutes to a standard exam and poses no extra risk. Researchers will co…

This study looks at 1,200 adults referred for liver checks to see if combining blood markers, genetic data, and gut bacteria analysis can detect liver scarring earlier than current methods. The goal is to identify advanced liver disease in the community and reduce unnecessary spe…

This study is collecting blood samples from 575 adults with fatty liver disease to find new, noninvasive tests that can detect liver scarring (fibrosis). Currently, doctors rely on a painful liver biopsy to check for scarring, but this research aims to replace that with a simple …

This study aims to better understand fatty liver disease in people aged 65 and older. Researchers will follow 20,000 participants from the community to identify lifestyle, environmental, and genetic factors that affect the disease. The goal is to create a health risk assessment s…

This study collects blood and tissue samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse tumors, to study these diseases and test new treatments. The goal is to improve unders…

This study looks at how common non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH, are in Olmsted County, Minnesota. Researchers will follow 800 adults over time to better diagnose these conditions and see how they affect long-term health, including risks f…

This early-stage study tests an experimental drug called HEC169584 in 96 healthy adults aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it, not to treat any disease. Results will help guide future studies for non-alcoholic steatohepatitis (…

This study uses tiny, lab-grown liver models (organoids) made from patient cells to understand how a specific gene variant (I148M of PNPLA3) contributes to non-alcoholic steatohepatitis (NASH), a serious fatty liver disease. Researchers will expose these mini-livers to fatty acid…

This study aims to find out why some people with fatty liver disease or alcohol-related liver disease develop liver cancer. Researchers will look at metabolic factors, immune system responses, and imaging data from 710 participants. The goal is to identify early warning signs, es…