NEURODEGENERATIVE DISEASES

This study tests a single dose of a gene therapy called NTLA-2001 in 60 people with a rare inherited nerve disease (ATTRv-PN). The goal is to see if it can safely reduce harmful protein buildup and slow nerve damage compared to a placebo. Participants must have a confirmed diagno…

This study tests whether a natural brain chemical called allopregnanolone can safely slow or reverse memory loss in Alzheimer's disease. About 100 people aged 55-80 with mild to moderate Alzheimer's will receive either the drug or a placebo for several months. The main goal is to…

This study tests whether a virtual reality (VR) platform can accurately measure thinking and movement skills, like balance, attention, and hand coordination. About 200 healthy volunteers and people with neurological conditions will take both standard tests and VR versions to see …

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study looks at whether increasing physical activity using a motivational smartphone app can slow down cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease. Researchers will enroll 80 people with iRBD and 50 health…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study aims to understand how inflammation affects the brain in Parkinson's disease. Researchers will give a mild inflammatory substance (LPS) to 30 participants, including people with Parkinson's and healthy volunteers, and use special brain scans to measure the response. Th…

This study looks at how speaking two languages (Spanish and English or Spanish and Catalan) affects language treatment in people with primary progressive aphasia (PPA), a condition that first causes speech and language problems. Researchers will give tailored speech therapy in bo…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study aims to find a new marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI). Researchers will track 44 people over time to see how certain brain cells change as the disease progresses. The goal is to better understand Parkinson's, not to test a…

This study uses PET, SPECT, and MRI brain scans to better understand brain changes in Parkinson's disease. Researchers hope to find a biomarker that can help develop new medications to slow symptom progression. The study involves 42 adults aged 25-85 with Parkinson's disease.

This study aims to find a biological marker for Parkinson's disease by using special brain scans (PET, SPECT, and MRI) in 45 people with certain genetic mutations. The goal is to better understand brain changes in Parkinson's and help develop new medications that could slow the d…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare nerve diseases that cause progressive muscle stiffness and disability. Researchers will analyze DNA from 200 children and adults with HSP to find gene variants linked to the cond…