NEUROBLASTOMA

This early-stage trial tested a new drug called CUDC-907 in 26 children and young adults (ages 1–21) with solid tumors, brain tumors, or lymphoma that had come back or stopped responding to treatment. The main goal was to find safe doses and understand side effects. Researchers a…

This early-phase study tested a new way to do stem cell transplants in 23 children whose solid tumors or lymphomas had come back. The method uses a special filter to remove certain immune cells from the donor's stem cells, aiming to help the child's body recover faster. The main …

This early-phase study tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that haven't responded to other treatments. Sixteen participants received chemotherapy t…

This phase 2 trial tested a combination of a radioactive drug (MIBG), intensive chemotherapy, and a stem cell transplant in 50 children with relapsed or hard-to-treat neuroblastoma. The goal was to see if this approach could shrink tumors and improve survival. The treatment aims …

This early-phase study tested a combination of three oral drugs (irinotecan, temozolomide, and cefixime) in 30 children whose high-risk neuroblastoma had come back or not responded to standard treatment. The goal was to find the safest dose of irinotecan when given with the other…

This early-phase study tested a daily pill called lorlatinib in 65 children and young adults with a type of nerve cancer (neuroblastoma) that had come back or not responded to treatment. The drug targets a specific genetic change (ALK) found in some tumors. The main goals were to…

This early-stage trial tested an oral powder form of the drug fenretinide (called LXS) in 80 children whose neuroblastoma had returned or resisted standard treatment. The main goals were to find the safest dose and understand side effects. Some patients also received ketoconazole…

This early-phase study tested a combination of two chemotherapy drugs (irinotecan and vincristine) plus a radioactive drug (131I-MIBG) in 26 children with high-risk neuroblastoma that had come back or not responded to standard treatment. The goal was to find the safest dose of th…

This early-phase study tested a type of radiation therapy called PRRT in children whose neuroblastoma had come back or did not respond to standard treatments. The goal was to find the safest dose of the radioactive drug 177Lu-DOTATATE. Only one child took part, and the study focu…

This study tested whether adding bevacizumab (a drug that cuts off a tumor's blood supply) to standard chemotherapy helps children aged 1-21 with neuroblastoma that has come back or not responded to treatment. 225 participants received different combinations of chemotherapy with …

This study tested whether adding an immunotherapy drug (Hu3F8) plus GM-CSF to standard treatment could help children with high-risk neuroblastoma stay in remission longer. Fifty-nine children who had already achieved remission after initial therapy received the combination along …

This study tested a new treatment for children with high-risk neuroblastoma, a type of cancer. Researchers took the patients' own immune cells (T cells) and modified them to recognize and attack the cancer. Some of these cells were also trained to fight a common virus (EBV) to he…

This study tested whether a smaller dose of radiation could control high-risk neuroblastoma while reducing long-term side effects. 78 children with high-risk neuroblastoma received reduced-dose radiotherapy. The main goal was to see if the tumor stayed under control at the origin…

This early-phase study tested a new approach for children with neuroblastoma that did not respond to standard treatments. It used two rapid infusions of a radioactive drug (I-MIBG) to target cancer cells, followed by a stem cell transplant to restore healthy blood cells. The goal…

This study tested a new antibody (hu14.18K322A) added to standard chemotherapy for 153 children with high-risk neuroblastoma, a serious nerve tissue cancer. The goal was to see if the combination improves tumor shrinkage and delays the cancer from coming back. While the treatment…

This early-phase study tested an intravenous form of the drug fenretinide in 17 children whose neuroblastoma had come back or didn't respond to standard treatments. The main goals were to find the safest dose and understand side effects. Researchers also looked at how the drug mo…

This study tested whether analyzing the DNA and RNA of a child's tumor could help doctors choose personalized treatments. It included 186 children with relapsed or hard-to-treat cancers like neuroblastoma and brain tumors. The goal was to see if this approach was feasible and saf…