NEPHROLITHIASIS

This study looks at the best time to use shock wave therapy (ESWL) to break up small leftover kidney stones after surgery. About 476 adults with stones 15 mm or smaller will be split into two groups: one gets ESWL within 1-2 weeks after surgery, the other waits 3-4 weeks. The goa…

This study compares standard kidney stone surgery (using a scope and laser) to the same surgery plus a special hydrogel that captures tiny stone fragments. The goal is to see if the gel helps remove more stone pieces, which could lower the chance of stones coming back. About 120 …

This study compares two standard surgical methods for removing kidney stones: mini-PCNL (a small incision in the back) and flexible ureteroscopy with a suction tube. The goal is to see which method leaves fewer stone fragments behind. About 80 adults with kidney stones between 1 …

This study compares two procedures for treating kidney stones that are 1 to 2 centimeters wide: shock wave therapy (ESWL) and laser surgery (RIRS). About 98 adults with a single stone will receive one of the treatments and be followed for 28 days. The goal is to see which method …

This study tests whether placing a numbing drug (bupivacaine) into the bladder after kidney stone surgery can lower pain and improve recovery. About 116 adults will receive either the drug or a saltwater placebo. The goal is to see if this simple step reduces pain, bladder spasms…

This study compares three different single-use flexible ureteroscopes used to remove kidney stones. Researchers will look at cost, how long surgery takes, complications, and how well the stones are cleared. The trial involves 180 adults aged 18 to 60 with kidney stones smaller th…

This study compares two FDA-approved lasers (Holmium:YAG with MOSES and thulium fiber) for breaking large kidney stones during a minimally invasive surgery called mini-PCNL. About 150 adults with stones larger than 15mm will be randomly assigned to one laser, both using a suction…

This study tests a simple change during kidney stone surgery: after removing the stone, doctors suction the kidney to make it collapse. The goal is to see if this lowers pain and infection risk after surgery. About 90 adults with kidney stones will take part, and half will get th…

This study looks at whether a 21-day spa program, including mineral water baths and exercise, can help people with chronic kidney and urinary tract problems. Researchers will check 150 adults (ages 40-70) before and after treatment using blood tests, urine tests, and quality-of-l…

This study looks at whether giving surgeons live information about pressure inside the kidney helps them make better decisions during stone-removal surgery. About 80 adults with large kidney stones will take part. The main goal is to see if the pressure data changes how the surge…

This study aims to see if a blood test that measures endotoxin levels can help predict which patients will develop infections after kidney stone surgery. Researchers will enroll 150 adults undergoing this surgery and track their endotoxin levels before and after the procedure. Th…