MYOCARDIAL ISCHEMIA

This study aimed to test the safety of injecting a gene therapy called VM202 directly into the heart muscle of people with severe, untreatable chest pain due to blocked arteries. The trial was withdrawn before enrolling any participants, so no results are available. The goal was …

This study tests whether ivabradine, a drug that slows the heart rate, can prevent heart injury in adults aged 45 and older undergoing noncardiac surgery. About 2,146 participants at high risk for heart problems will receive either ivabradine or a placebo. The goal is to see if t…

This study compares two drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in three heart arteries. Participants receive modern heart care including imaging and medications. The goal is to see which stent is safer and more effective at pre…

This study tests whether using personalized risk models can safely reduce the number of diagnostic tests needed for people with new, stable chest pain. Researchers will compare this approach to standard care in 2000 adults aged 30-75. They will also test a new laser method to mea…

This study compares a new method for diagnosing heart attacks—focusing on whether a coronary artery is fully blocked (occlusion) or not—to the standard ST-elevation approach. Researchers will enroll 6,000 adults with suspected heart attacks to see if the new method better predict…

This study tests a new PET heart scan that uses 10 to 100 times less radiation than current methods. It involves 200 adults with known or suspected heart artery disease. Participants get a tiny dose of a radioactive tracer and are scanned for up to 3 hours to see if the images ar…

This study tests whether briefly inflating a blood-pressure cuff on the arm before surgery can reduce heart damage in high-risk patients. Over 1,200 adults undergoing non-cardiac surgery will be randomly assigned to receive the cuff procedure or a sham. The goal is to see if this…

This study looks at whether combining stress echocardiogram results with routine health information (like blood pressure and diabetes) can better predict major heart problems, such as heart attacks or strokes, in adults with chest pain. Researchers will use artificial intelligenc…

This study follows 500 people with peripheral artery disease (narrowed leg arteries) who undergo a procedure to restore blood flow. Researchers check blood for heart-damage markers and use heart ultrasound to find silent injuries that may raise future heart attack or stroke risk.…

This study looks at why some women with heart disease symptoms have clear major arteries but still have chest pain or stress test issues. Researchers think tiny heart vessels or blood clotting problems may be the cause. About 206 women will have extra tests during their heart cat…

This study looks at how doctors use a special camera called OCT to guide heart artery treatments in everyday practice. About 2000 adults with reduced blood flow to the heart will be observed. The goal is to see if a new method called MLD-MAX helps place stents more accurately, po…

This study looks at 600 older adults (65+) having major hip or knee surgery to see if a computer model can predict heart injury after surgery. Researchers combine frailty scores, blood tests, and other health data to find who is at highest risk. The goal is to help doctors better…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …