MUSCLE-INVASIVE BLADDER CANCER

This study tests a combination of two drugs, enfortumab vedotin and pembrolizumab, for people with muscle-invasive bladder cancer. The goal is to see if this treatment can control the cancer and allow patients to keep their bladder instead of having it surgically removed. The stu…

This study tests whether giving two drugs together after surgery can keep bladder cancer from returning in patients at high risk. About 23 adults who have had their bladder or part of their urinary tract removed will receive sacituzumab govitecan and nivolumab. The goal is to see…

This study tests a drug called erdafitinib, alone or with another drug (cetrelimab), given before surgery to people with muscle-invasive bladder cancer whose tumors have certain gene changes. The goal is to see if these treatments can shrink or eliminate the cancer before the bla…

This study tests whether a special MRI scan, followed by a same-day biopsy, can diagnose muscle-invasive bladder cancer faster and more accurately than the usual surgery (TURBT). About 360 adults with suspected aggressive bladder cancer will be randomly assigned to one of the two…

This study compares a special MRI scan (mpMRI) to the standard surgical biopsy (TURBT) for diagnosing muscle-invasive bladder cancer. Researchers want to see if the MRI can accurately detect cancer invasion into the bladder muscle, which could help some patients avoid an invasive…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …

This study looks at whether chemotherapy given before bladder cancer surgery makes MRI scans less accurate at showing the tumor stage. About 76 people with muscle-invasive bladder cancer will take part. Some will get chemotherapy before surgery, and others will go straight to sur…