METASTATIC SOLID TUMOR

This study tests a new drug called LY4066434 in people with advanced solid tumors that have certain KRAS mutations. The main goal is to see if the drug is safe and tolerable when given alone or with other treatments. About 750 participants with cancers like pancreatic, lung, or c…

This early-phase study tests a new drug called LP-184 in 64 adults with advanced solid tumors (like pancreatic, lung, or breast cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow their …

This early-phase study tests a new drug called WTX-124, either alone or combined with pembrolizumab, in 150 people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose, while also seeing if the drug …

This early-phase study tests whether a drug called AZD1390, given together with a precise type of radiation (SBRT), is safe for people whose solid tumors have spread to other parts of the body. About 54 adults with metastatic cancer will receive increasing doses of the drug along…

This early-phase study tests an experimental drug called MOMA-313, given alone or with another drug (olaparib), in people with advanced solid tumors that have a specific DNA repair problem (HR deficiency). The main goals are to check safety, find the best dose, and see if the dru…

This early-stage study tests a new treatment using a patient's own immune cells (called M-CENK) combined with a drug (N-803) to fight advanced solid tumors that have spread. The study includes two groups: one with newly diagnosed or first-line treated patients, and another with p…

This study tests an experimental drug called TransCon IL-2 β/γ, given alone or with other cancer treatments, for adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find safe doses and check for side effects. About 320 partici…

This early-phase study tests a new drug called LY4101174 in people with advanced or metastatic solid tumors that have come back or spread. The drug is designed to target and attack cancer cells while sparing healthy ones. The study will check if the drug is safe and what dose wor…

This early-phase study tests a new drug called DS-1055a in about 40 adults with advanced solid tumors (like head and neck, stomach, or lung cancer) that have not responded to standard treatments. The main goal is to check the drug's safety and find the right dose. Participants re…

This study tests a drug called sacituzumab govitecan in 227 people whose solid tumors have spread to other parts of the body. The goal is to see if the drug can shrink or control the cancer. Participants must have already tried standard treatments like chemotherapy or immunothera…

This study looks back at medical records of 72 American Indian patients treated with immunotherapy for different cancers. Researchers want to see how long these patients lived without their cancer getting worse, their overall survival, and side effects compared to White patients.…