METASTATIC SARCOMA

This early-phase trial tests a new two-drug combination for people with advanced soft tissue sarcomas that have spread or can't be removed by surgery. The study combines a standard chemotherapy (liposomal doxorubicin) with an experimental drug (peposertib) that may help the chemo…

This study is for children, teens, and young adults (up to age 39) with sarcoma that has spread to a few other places in the body. The goal is to see if giving radiation to those spread spots, along with standard treatment, can help them live longer without the cancer getting wor…

This study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to the bones. About 40 adults with certain advanced cancers (like prostate, kidney, or colorectal) will be enrolle…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…

This study tests a rice-sized device that is temporarily placed inside a tumor to release tiny amounts of up to 10 different drugs. The goal is to see which drugs kill the most cancer cells without affecting the whole body. About 20 people with sarcoma that has spread or returned…