METASTATIC COLORECTAL CANCER (CRC)

This phase 3 study tests whether a new drug called ivonescimab, when added to standard chemotherapy, works better than the current standard treatment (bevacizumab plus chemo) for people with metastatic colorectal cancer that has spread. About 600 adults who have not had prior tre…

This study tests whether a new chemotherapy combination (NALIRIFOX) plus targeted therapy works better than the standard treatment (FOLFOX) plus targeted therapy for people with metastatic colorectal cancer that cannot be removed by surgery. About 144 adults who have not had prio…

This study tests a new combination of chemotherapy (5FU-based) plus the targeted drug fruquintinib as a first treatment for people with advanced colorectal cancer that cannot be removed by surgery or has spread. About 50 participants will receive the treatment in cycles, and afte…

This early-stage trial tests a personalized T-cell therapy called iNeo-Vac-T01 for people with advanced colorectal cancer that has not responded to standard treatments. The therapy is custom-made for each patient based on their tumor's unique genetic markers. The study aims to se…

This early-phase study tests a new drug called BBO-11818 in people with advanced solid tumors (lung, pancreatic, colorectal, or others) that have a specific KRAS gene mutation. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Abo…

This study tests whether taking cannabidiol (CBD) capsules can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. About 30 participants will be randomly assigned to receive either CBD plus standard treatment or standard treatme…

This study looks at whether a simple blood test (ctDNA) can help doctors decide which patients with metastatic colorectal cancer might benefit from retreatment with a targeted therapy called anti-EGFR. Researchers will collect and analyze data from 250 patients who have already h…