Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New hope for advanced colon cancer: experimental drug combo enters phase 3 trial

NCT ID NCT07228832

Disease control Sponsor: Summit Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 8 times

Summary

This phase 3 study tests whether a new drug called ivonescimab, combined with standard chemotherapy (FOLFOX), works better than the current standard treatment (bevacizumab plus FOLFOX) for people with metastatic colorectal cancer that has spread. About 600 adults who have not had prior treatment for their advanced cancer will take part. The main goal is to see if the new combination delays cancer growth and improves survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. ECOG performance status score of 0 or 1 2. Expected life expectancy ≥ 6 months 3. Patients with histologically or cytologically confirmed metastatic CRC 4. No prior systemic therapy for metastatic CRC 5. At least 1 measurable noncerebral lesion Exclusion Criteria: 1. Microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) disease 2. Known BRAF V600E mutant status 3. Current presence of significant radiographic or clinical manifestations of gastrointestinal (GI) obstruction 4. Ascites requiring paracentesis within last 30 days 5. Patients who have received prior immunotherapy or anti-angiogenic therapy for colorectal cancer 6. Active or prior history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea) 7. Resectable disease

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Metastatic colorectal cancer (CRC) are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic colorectal cancer (CRC)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    213 sites in 14 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Clinical Study Site

    RECRUITING

    Mobile, Alabama, 36604, United States

  • Clinical Study Site

    RECRUITING

    Tuscaloosa, Alabama, 35487, United States

  • Clinical Study Site

    RECRUITING

    Goodyear, Arizona, 85338, United States

  • Clinical Study Site

    RECRUITING

    Beverly Hills, California, 90211, United States

  • Clinical Study Site

    RECRUITING

    Beverly Hills, California, 90212, United States

  • Clinical Study Site

    RECRUITING

    Cerritos, California, 90703, United States

  • Clinical Study Site

    RECRUITING

    Corona, California, 92882, United States

  • Clinical Study Site

    RECRUITING

    Duarte, California, 91010, United States

  • Clinical Study Site

    RECRUITING

    Fountain Valley, California, 92708, United States

  • Clinical Study Site

    RECRUITING

    Huntington Beach, California, 92648, United States

  • Clinical Study Site

    RECRUITING

    Irvine, California, 92612, United States

  • Clinical Study Site

    RECRUITING

    Irvine, California, 92618, United States

  • Clinical Study Site

    RECRUITING

    Los Angeles, California, 90027, United States

  • Clinical Study Site

    RECRUITING

    Los Angeles, California, 90067, United States

  • Clinical Study Site

    RECRUITING

    Los Angeles, California, 90404, United States

  • Clinical Study Site

    RECRUITING

    Murrieta, California, 92562, United States

  • Clinical Study Site

    RECRUITING

    Oakland, California, 94611, United States

  • Clinical Study Site

    RECRUITING

    Orange, California, 92868, United States

  • Clinical Study Site

    RECRUITING

    Pasadena, California, 91030, United States

  • Clinical Study Site

    RECRUITING

    Roseville, California, 95661, United States

  • Clinical Study Site

    RECRUITING

    San Francisco, California, 94115, United States

  • Clinical Study Site

    RECRUITING

    Santa Clara, California, 94115, United States

  • Clinical Study Site

    RECRUITING

    Stanford, California, 94305, United States

  • Clinical Study Site

    RECRUITING

    Torrance, California, 90503, United States

  • Clinical Study Site

    RECRUITING

    Upland, California, 91786, United States

  • Clinical Study Site

    RECRUITING

    Vallejo, California, 94589, United States

  • Clinical Study Site

    RECRUITING

    West Hollywood, California, 90048, United States

  • Clinical Study Site

    RECRUITING

    Hartford, Connecticut, 06106, United States

  • Clinical Study Site

    RECRUITING

    New Haven, Connecticut, 06520-8028, United States

  • Clinical Study Site

    RECRUITING

    Norwich, Connecticut, 06360, United States

  • Clinical Study Site

    RECRUITING

    Newark, Delaware, 19713, United States

  • Clinical Study Site

    RECRUITING

    Hialeah, Florida, 33013, United States

  • Clinical Study Site

    RECRUITING

    Miami, Florida, 33176, United States

  • Clinical Study Site

    RECRUITING

    Miami Beach, Florida, 33140, United States

  • Clinical Study Site

    RECRUITING

    Ocala, Florida, 34474, United States

  • Clinical Study Site

    RECRUITING

    Orlando, Florida, 32804, United States

  • Clinical Study Site

    RECRUITING

    Orlando, Florida, 32806, United States

  • Clinical Study Site

    RECRUITING

    Plantation, Florida, 33322, United States

  • Clinical Study Site

    RECRUITING

    Port Saint Lucie, Florida, 34952, United States

  • Clinical Study Site

    RECRUITING

    St. Petersburg, Florida, 33705, United States

  • Clinical Study Site

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Clinical Study Site

    RECRUITING

    Atlanta, Georgia, 30303, United States

  • Clinical Study Site

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Clinical Study Site

    RECRUITING

    Newnan, Georgia, 30265, United States

  • Clinical Study Site

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Clinical Study Site

    RECRUITING

    Elmhurst, Illinois, 60540, United States

  • Clinical Study Site

    RECRUITING

    O'Fallon, Illinois, 62269, United States

  • Clinical Study Site

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • Clinical Study Site

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Clinical Study Site

    RECRUITING

    Westwood, Kansas, 66205, United States

  • Clinical Study Site

    RECRUITING

    Edgewood, Kentucky, 41017, United States

  • Clinical Study Site

    RECRUITING

    New Orleans, Louisiana, 70121, United States

  • Clinical Study Site

    RECRUITING

    Baltimore, Maryland, 21201, United States

  • Clinical Study Site

    RECRUITING

    Detroit, Michigan, 48201, United States

  • Clinical Study Site

    RECRUITING

    Saint Louis Park, Minnesota, 55426, United States

  • Clinical Study Site

    RECRUITING

    Springfield, Missouri, 65804, United States

  • Clinical Study Site

    RECRUITING

    Billings, Montana, 59102, United States

  • Clinical Study Site

    RECRUITING

    Lincoln, Nebraska, 68506, United States

  • Clinical Study Site

    RECRUITING

    Lebanon, New Hampshire, 03766, United States

  • Clinical Study Site

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Clinical Study Site

    RECRUITING

    Mineola, New York, 11501, United States

  • Clinical Study Site

    RECRUITING

    New York, New York, 10016, United States

  • Clinical Study Site

    RECRUITING

    Rochester, New York, 14642, United States

  • Clinical Study Site

    RECRUITING

    Syracuse, New York, 13210, United States

  • Clinical Study Site

    RECRUITING

    The Bronx, New York, 10461, United States

  • Clinical Study Site

    RECRUITING

    White Plains, New York, 10601-5000, United States

  • Clinical Study Site

    RECRUITING

    Pinehurst, North Carolina, 28374, United States

  • Clinical Study Site

    RECRUITING

    Akron, Ohio, 44032, United States

  • Clinical Study Site

    RECRUITING

    Canton, Ohio, 44703, United States

  • Clinical Study Site

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • Clinical Study Site

    RECRUITING

    Cincinnati, Ohio, 45220, United States

  • Clinical Study Site

    RECRUITING

    Cleveland, Ohio, 44111, United States

  • Clinical Study Site

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Clinical Study Site

    RECRUITING

    Mayfield Heights, Ohio, 44124, United States

  • Clinical Study Site

    RECRUITING

    Oklahoma City, Oklahoma, 73120, United States

  • Clinical Study Site

    RECRUITING

    Lebanon, Pennsylvania, 17042, United States

  • Clinical Study Site

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Clinical Study Site

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

  • Clinical Study Site

    RECRUITING

    Philadelphia, Pennsylvania, 19140, United States

  • Clinical Study Site

    RECRUITING

    Pittsburgh, Pennsylvania, 15212, United States

  • Clinical Study Site

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Clinical Study Site

    RECRUITING

    Sellersville, Pennsylvania, 18960, United States

  • Clinical Study Site

    RECRUITING

    Providence, Rhode Island, 02903, United States

  • Clinical Study Site

    RECRUITING

    Greenville, South Carolina, 29605, United States

  • Clinical Study Site

    RECRUITING

    Spartanburg, South Carolina, 29303, United States

  • Clinical Study Site

    RECRUITING

    Germantown, Tennessee, 38138, United States

  • Clinical Study Site

    RECRUITING

    Hermitage, Tennessee, 37129, United States

  • Clinical Study Site

    RECRUITING

    Dallas, Texas, 75235, United States

  • Clinical Study Site

    RECRUITING

    Dallas, Texas, 75390, United States

  • Clinical Study Site

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • Clinical Study Site

    RECRUITING

    Houston, Texas, 77026, United States

  • Clinical Study Site

    RECRUITING

    Houston, Texas, 77030, United States

  • Clinical Study Site

    RECRUITING

    Tyler, Texas, 75701, United States

  • Clinical Study Site

    RECRUITING

    Salt Lake City, Utah, 84106, United States

  • Clinical Study Site

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Clinical Study Site

    RECRUITING

    Burlington, Vermont, 05401, United States

  • Clinical Study Site

    RECRUITING

    Charlottesville, Virginia, 22908, United States

  • Clinical Study Site

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Clinical Study Site

    RECRUITING

    Spokane, Washington, 99208, United States

  • Clinical Study Site

    RECRUITING

    Tacoma, Washington, 98405, United States

  • Clinical Study Site

    RECRUITING

    Charleston, West Virginia, 25304, United States

  • Clinical Study Site

    RECRUITING

    Madison, Wisconsin, 53792, United States

  • Clinical Study Site

    RECRUITING

    Brussels, 1000, Belgium

  • Clinical Study Site

    RECRUITING

    Ghent, 9000, Belgium

  • Clinical Study Site

    RECRUITING

    Haine-Saint-Paul, 7100, Belgium

  • Clinical Study Site

    RECRUITING

    Kortrijk, 8500, Belgium

  • Clinical Study Site

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • Clinical Study Site

    RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

  • Clinical Study Site

    RECRUITING

    Regina, Saskatchewan, S4T7T1, Canada

  • Clinical Study Site

    RECRUITING

    Beijing, Beijing Municipality, 100020, China

  • Clinical Study Site

    RECRUITING

    Fuzhou, Fujian, 350014, China

  • Clinical Study Site

    RECRUITING

    Guangzhou, Fujian, 350004, China

  • Clinical Study Site

    RECRUITING

    Foshan, Guangdong, 528000, China

  • Clinical Study Site

    RECRUITING

    Guangzhou, Guangdong, 510630, China

  • Clinical Study Site

    RECRUITING

    Shenzhen, Guangdong, 518101, China

  • Clinical Study Site

    RECRUITING

    Haikou, Hainan, 570145, China

  • Clinical Study Site

    RECRUITING

    Shijiazhuang, Hebei, 50011, China

  • Clinical Study Site

    RECRUITING

    Harbin, Heilongjiang, 150081, China

  • Clinical Study Site

    RECRUITING

    Fuzhou, Henan, 455000, China

  • Clinical Study Site

    RECRUITING

    Zhengzhou, Henan, 450052, China

  • Clinical Study Site

    RECRUITING

    Wuhan, Hubei, 430022, China

  • Clinical Study Site

    RECRUITING

    Changsha, Hunan, 410013, China

  • Clinical Study Site

    RECRUITING

    Yueyang, Hunan, 414020, China

  • Clinical Study Site

    RECRUITING

    Chifeng, Inner Mongolia, 24000, China

  • Clinical Study Site

    RECRUITING

    Nanjing, Jiangsu, 210009, China

  • Clinical Study Site

    RECRUITING

    Nanchang, Jiangxi, 330006, China

  • Clinical Study Site

    RECRUITING

    Ch’ang-ch’un, Jilin, 130012, China

  • Clinical Study Site

    RECRUITING

    Shenyang, Liaoning, 110001, China

  • Clinical Study Site

    RECRUITING

    Jinan, Shandong, 250021, China

  • Clinical Study Site

    RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

  • Clinical Study Site

    RECRUITING

    Chengdu, Sichuan, 610041, China

  • Clinical Study Site

    RECRUITING

    Luzhou, Sichuan, 646000, China

  • Clinical Study Site

    RECRUITING

    Kunming, Yunnan, 650118, China

  • Clinical Study Site

    RECRUITING

    Hangzhou, Zhejiang, 310009, China

  • Clinical Study Site

    RECRUITING

    Hangzhou, Zhejiang, 310022, China

  • Clinical Study Site

    RECRUITING

    Ningbo, Zhejiang, 315040, China

  • Clinical Study Site

    RECRUITING

    Wenzhou, Zhejiang, 325000, China

  • Clinical Study Site

    RECRUITING

    Hradec Králové, 50005, Czechia

  • Clinical Study Site

    RECRUITING

    Olomouc, 779 00, Czechia

  • Clinical Study Site

    RECRUITING

    Prague, 128 00, Czechia

  • Clinical Study Site

    RECRUITING

    Prague, 14059, Czechia

  • Clinical Study Site

    RECRUITING

    Bordeaux, 33076, France

  • Clinical Study Site

    RECRUITING

    Lille, 59000, France

  • Clinical Study Site

    RECRUITING

    Lyon, 69374, France

  • Clinical Study Site

    RECRUITING

    Montpellier, 34298, France

  • Clinical Study Site

    RECRUITING

    Nantes, 44000, France

  • Clinical Study Site

    RECRUITING

    Nice, 06189, France

  • Clinical Study Site

    RECRUITING

    Paris, 75015, France

  • Clinical Study Site

    RECRUITING

    Paris, 75020, France

  • Clinical Study Site

    RECRUITING

    Pierre-Bénite, 69495, France

  • Clinical Study Site

    RECRUITING

    Poitiers, 86000, France

  • Clinical Study Site

    RECRUITING

    Strasbourg, 67033, France

  • Clinical Study Site

    RECRUITING

    Berlin, 13353, Germany

  • Clinical Study Site

    RECRUITING

    Bonn, 53113, Germany

  • Clinical Study Site

    RECRUITING

    Hamburg, 20249, Germany

  • Clinical Study Site

    RECRUITING

    Hamburg, 22763, Germany

  • Clinical Study Site

    RECRUITING

    Budapest, 1122, Hungary

  • Clinical Study Site

    RECRUITING

    Debrecen, 4032, Hungary

  • Clinical Study Site

    RECRUITING

    Kecskemét, H-6000, Hungary

  • Clinical Study Site

    RECRUITING

    Brescia, 25124, Italy

  • Clinical Study Site

    RECRUITING

    Florence, 50134, Italy

  • Clinical Study Site

    RECRUITING

    Genova, 16132, Italy

  • Clinical Study Site

    RECRUITING

    Meldola, 47014, Italy

  • Clinical Study Site

    RECRUITING

    Pisa, 56126, Italy

  • Clinical Study Site

    RECRUITING

    Verona, 37134, Italy

  • Clinical Study Site

    RECRUITING

    Osaka, Ontario, 565-0871, Japan

  • Clinical Study Site

    RECRUITING

    Aichi, 464-8681, Japan

  • Clinical Study Site

    RECRUITING

    Chiba, 260-8717, Japan

  • Clinical Study Site

    RECRUITING

    Ehime, 791-0280, Japan

  • Clinical Study Site

    RECRUITING

    Fukuoka, 812-8582, Japan

  • Clinical Study Site

    RECRUITING

    Gifu, 501-1194, Japan

  • Clinical Study Site

    RECRUITING

    Hiroshima, 734-8551, Japan

  • Clinical Study Site

    RECRUITING

    Hokkaido, 060-8648, Japan

  • Clinical Study Site

    RECRUITING

    Kawasaki, 216-8511, Japan

  • Clinical Study Site

    RECRUITING

    Osaka, 541-8567, Japan

  • Clinical Study Site

    RECRUITING

    Saitama, 362-0806, Japan

  • Clinical Study Site

    RECRUITING

    Sendai, 980-0872, Japan

  • Clinical Study Site

    RECRUITING

    Shizuoka, 411-8777, Japan

  • Clinical Study Site

    RECRUITING

    Tokyo, 104-0045, Japan

  • Clinical Study Site

    RECRUITING

    Tokyo, 113-8677, Japan

  • Clinical Study Site

    RECRUITING

    Tokyo, 135-8550, Japan

  • Clinical Study Site

    RECRUITING

    Toyama, 930-0194, Japan

  • Clinical Study Site

    RECRUITING

    Yokohama, 241-8515, Japan

  • Clinical Study Site

    RECRUITING

    Rzeszów, Podkarpackie Voivodeship, 35-021, Poland

  • Clinical Study Site

    RECRUITING

    Gdansk, 80-219, Poland

  • Clinical Study Site

    RECRUITING

    Olsztyn, 10-228, Poland

  • Clinical Study Site

    RECRUITING

    Otwock, 05-400, Poland

  • Clinical Study Site

    RECRUITING

    Warsaw, 02-781, Poland

  • Clinical Study Site

    RECRUITING

    Warsaw, 04-141, Poland

  • Clinical Study Site

    RECRUITING

    Rio Piedras, 00935, Puerto Rico

  • Clinical Study Site

    RECRUITING

    A Coruña, 15006, Spain

  • Clinical Study Site

    RECRUITING

    Barcelona, 08035, Spain

  • Clinical Study Site

    RECRUITING

    Barcelona, 08036, Spain

  • Clinical Study Site

    RECRUITING

    Barcelona, 08908, Spain

  • Clinical Study Site

    RECRUITING

    Barcelona, 08916, Spain

  • Clinical Study Site

    RECRUITING

    Granada, 18014, Spain

  • Clinical Study Site

    RECRUITING

    Madrid, 28009, Spain

  • Clinical Study Site

    RECRUITING

    Madrid, 28046, Spain

  • Clinical Study Site

    RECRUITING

    Madrid, 28050, Spain

  • Clinical Study Site

    RECRUITING

    Madrid, 28222, Spain

  • Clinical Study Site

    RECRUITING

    Málaga, 29010, Spain

  • Clinical Study Site

    RECRUITING

    Palma de Mallorca, 07198, Spain

  • Clinical Study Site

    RECRUITING

    Santander, 39008, Spain

  • Clinical Study Site

    RECRUITING

    Seville, 41013, Spain

  • Clinical Study Site

    RECRUITING

    Valencia, 46010, Spain

  • Clinical Study Site

    RECRUITING

    Valencia, 46014, Spain

  • Clinical Study Site

    RECRUITING

    Valencia, 46026, Spain

  • Clinical Study Site

    RECRUITING

    Canterbury, England, CT13NS, United Kingdom

  • Clinical Study Site

    RECRUITING

    London, England, EC1M 6BQ, United Kingdom

  • Clinical Study Site

    RECRUITING

    Aberdeen, Scotland, AB25 2ZN, United Kingdom

  • Clinical Study Site

    RECRUITING

    Edinburgh, EH4 2XU, United Kingdom

  • Clinical Study Site

    RECRUITING

    Liverpool, L7 8YA, United Kingdom

  • Clinical Study Site

    RECRUITING

    Manchester, M20 4BX, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.