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Researchers hunt for clues to improve colorectal cancer Drug's success

NCT ID NCT07124858

Knowledge-focused Sponsor: Federation Francophone de Cancerologie Digestive Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tracks 300 adults with advanced colorectal cancer who are taking the drug fruquintinib. Researchers want to find out which patient or tumor features help the drug work best and improve survival. The goal is to learn from real-world use to better match patients with effective treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 and over. * Histologically confirmed colorectal adenocarcinoma with locally advanced disease and/or unresectable metastasis(es) receiving treatment with fruquintinib under i) compassionate/early access and ii) marketing authorisation and reimbursement in France. * Obtain informed consent from the patient for the clinical-biological cohort. * Agreement to take biological samples of ctDNA and send tumour blocks (patient participation in the pharmacokinetic study remains optional). Exclusion Criteria: * Patient with another concurrent cancer at the time of diagnosis, requiring systemic treatment or influencing prognosis (in the opinion of the centre's medical team). * Contraindication due to psychological or social reasons that may hinder follow-up (cognitive deficit, psychological disorders incompatible with obtaining consent; inability to be followed in the same centre throughout the follow-up period for geographical reasons). * Pregnant or breast-feeding women. * Patients under court protection or subject to a protective measure (patient under guardianship or curatorship).

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antineoplastic agents, immunological Metastatic colorectal cancer (CRC) Vegfr-tki

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    83 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • BICHAT

    RECRUITING

    Paris, France

  • CH de la source

    RECRUITING

    Orléans, France

  • CHI

    RECRUITING

    Fréjus, France

  • CHU

    RECRUITING

    Amiens, France

  • CHU

    RECRUITING

    Besançon, France

  • CHU

    RECRUITING

    Brest, France

  • CHU

    RECRUITING

    Caen, France

  • CHU

    RECRUITING

    Lille, France

  • CHU

    RECRUITING

    Limoges, France

  • CHU

    RECRUITING

    Pessac, France

  • CHU

    RECRUITING

    Poitiers, France

  • CHU

    RECRUITING

    Reims, France

  • CHU

    RECRUITING

    Rennes, France

  • CHU

    RECRUITING

    Rouen, France

  • CHU

    RECRUITING

    Tours, France

  • CHU

    RECRUITING

    Vandœuvre-lès-Nancy, France

  • COCHIN

    RECRUITING

    Paris, France

  • Centre Cario

    RECRUITING

    Plérin, France

  • Centre Hospitalier

    RECRUITING

    Albi, France

  • Centre Hospitalier

    RECRUITING

    Annecy, France

  • Centre Hospitalier

    RECRUITING

    Aurillac, France

  • Centre Hospitalier

    RECRUITING

    Bayeux, France

  • Centre Hospitalier

    RECRUITING

    Bayonne, France

  • Centre Hospitalier

    RECRUITING

    Beauvais, France

  • Centre Hospitalier

    RECRUITING

    Calais, France

  • Centre Hospitalier

    RECRUITING

    Chartres, France

  • Centre Hospitalier

    RECRUITING

    Cholet, France

  • Centre Hospitalier

    RECRUITING

    Flers, France

  • Centre Hospitalier

    RECRUITING

    Le Puy-en-Velay, France

    Contact Email: •••••@•••••

  • Centre Hospitalier

    RECRUITING

    Lens, France

  • Centre Hospitalier

    RECRUITING

    Niort, France

  • Centre Hospitalier

    RECRUITING

    Pau, France

  • Centre Hospitalier

    RECRUITING

    Perpignan, France

  • Centre Hospitalier

    RECRUITING

    Saint-Denis, France

  • Centre Hospitalier

    RECRUITING

    Soissons, France

  • Centre Hospitalier

    RECRUITING

    St-Malo, France

  • Centre Hospitalier

    RECRUITING

    Thonon-les-Bains, France

  • Centre Hospitalier

    RECRUITING

    Versailles, France

  • Centre Hospitalier Bethune Beuvry

    RECRUITING

    Beuvry, France

  • Centre Hospitalier Henri Mondor

    RECRUITING

    Créteil, France

  • Centre Hospitalier Sud Francilien

    RECRUITING

    Corbeil-Essonnes, France

  • Centre Hospitalier de Vendee

    RECRUITING

    La Roche-sur-Yon, France

  • Centre Leonard de Vinci

    RECRUITING

    Dechy, France

  • Centre Pierre Curie

    RECRUITING

    Beuvry, France

  • Ch Du Mittan

    RECRUITING

    Montbéliard, France

  • Chu Francois Mitterand

    RECRUITING

    Dijon, France

  • Chu Rangueil

    RECRUITING

    Toulouse, France

  • Clinique Ambroise Pare Hartmann

    RECRUITING

    Neuilly, France

  • Clinique Branche - Clinique Flandres

    RECRUITING

    Coudekerque-Branche, France

  • Clinique Gray

    RECRUITING

    Maubeuge, France

  • Clinique Jean Mermoz

    RECRUITING

    Lyon, France

  • Clinique Sainte Anne

    RECRUITING

    Strasbourg, France

  • Clinique Sainte Clothilde

    RECRUITING

    La Réunion, France

  • Clinique Sainte Come

    RECRUITING

    Compiègne, France

  • Clinique Sainte Marie

    RECRUITING

    Chalon-sur-Saône, France

  • Clinique Tivoli

    RECRUITING

    Bordeaux, France

  • Clinique de L Europe

    RECRUITING

    Amiens, France

  • Groupe Hospitalier Diaconesses Croix Saint Simon

    RECRUITING

    Paris, France

  • Groupe Hospitalier Mutualiste

    RECRUITING

    Grenoble, France

  • Groupement Hospitalier Bretagne Sud

    RECRUITING

    Lorient, France

  • Hopital Americain

    RECRUITING

    Neuilly-sur-Seine, France

  • Hopital Avicenne

    RECRUITING

    Paris, France

  • Hopital Europeen

    RECRUITING

    Marseille, France

  • Hopital Instruction Des Armees

    RECRUITING

    Percy, France

  • Hopital Nord Ouest

    RECRUITING

    Villefranche-sur-Saône, France

  • Hopital Prive Confluent

    RECRUITING

    Nantes, France

  • Hopital Prive Drome Ardeche

    RECRUITING

    Valence, France

  • Hopital Prive Forcilles

    RECRUITING

    Férolles-Attilly, France

    Contact Email: •••••@•••••

  • Hopital Prive de L Estuaire

    RECRUITING

    Le Havre, France

  • Hopital Saint Joseph

    RECRUITING

    Marseille, France

  • Hopital Saint Louis

    RECRUITING

    Paris, France

  • Infirmerie Protestante

    RECRUITING

    Caluire-et-Cuire, France

  • Institut de Cancerologie de Bourgogne

    RECRUITING

    Dijon, France

  • Institut de Cancerologie de Lorraine

    RECRUITING

    Nancy, France

  • La Pitie Salepetriere

    RECRUITING

    Paris, France

  • La Timone

    RECRUITING

    Marseille, France

  • Lyon Sud

    RECRUITING

    Pierre-Bénite, France

  • Medipole Hopital Mutualiste

    RECRUITING

    Villeurbanne, France

  • Poitiers CHU

    RECRUITING

    Poitiers, France, 86021, France

  • Polyclinique de Blois

    RECRUITING

    La Chaussée-Saint-Victor, France

  • Polynclinique Bordeaux Nord Aquitaine

    RECRUITING

    Bordeaux, France

  • ROC37

    RECRUITING

    Chambray-lès-Tours, France

  • Saint Antoine

    RECRUITING

    Paris, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.