Metastatic colorectal cancer (CRC)
Clinical trials for Metastatic colorectal cancer (CRC) explained in plain language.
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Replacing the whole liver: a radical bid to outlast colorectal cancer
Cure Not yet recruitingThis study tests whether liver transplantation can extend survival for adults with colorectal cancer that has spread only to the liver and cannot be removed or destroyed by local treatments. About 260 participants aged 18 to 65 will receive a new liver from a deceased or living d…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Sponsor: Charite University, Berlin, Germany • Aim: Cure
Last updated Sep 12, 2026 00:00 UTC
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Can a pill target a Hard-to-Treat colorectal cancer?
Disease control Not yet recruitingThis trial tests an experimental oral drug called DES-1357 in adults with metastatic colorectal cancer that has specific genetic features (dMMR or MSI-H). The study runs in three parts: first, to find a safe dose; second, to check tolerability and early signs of tumor shrinkage; …
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 1/2 • Sponsor: D. E. Shaw Research, LLC • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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New chemo cocktail aims to slow advanced colon cancer
Disease control Not yet recruitingThis study tests a new chemotherapy regimen called FOLFOX8 against the standard mFOLFOX6, both combined with targeted drugs (bevacizumab or cetuximab), as a first treatment for people with metastatic colorectal cancer that cannot be surgically removed. About 229 participants will…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New cocktail attack on stubborn colon cancer
Disease control Not yet recruitingThis phase 2 trial is testing a combination of two targeted drugs (fruquintinib and serplulimab) plus chemotherapy as a first treatment for 80 people with advanced colorectal cancer that has RAS or BRAF mutations. The goal is to see if this mix can delay cancer growth and improve…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: Jiangsu Cancer Institute & Hospital • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New drug combo aims to shrink tumors in advanced colorectal cancer
Disease control Not yet recruitingThis study tests whether a new form of chemotherapy (liposomal irinotecan) combined with other drugs works better than standard irinotecan for people with metastatic colorectal cancer that has progressed after first-line treatment. About 408 adults aged 18 to 75 will be randomly …
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2/3 • Sponsor: Hebei Medical University Fourth Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New personalized vaccine takes on tough cancers
Disease control Not yet recruitingThis early-stage trial tests a personalized cancer vaccine called ODI-2001 in 77 people with advanced colon or pancreatic cancer that has spread or cannot be removed. The vaccine is custom-made for each patient's tumor and is given along with a drug that boosts the immune system.…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 1 • Sponsor: Centre Georges Francois Leclerc • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New hope for advanced colon cancer: drug cocktail trial launches
Disease control Not yet recruitingThis study tests a new combination of drugs for people with advanced colorectal cancer that cannot be removed by surgery. About 70 participants will receive two immunotherapy drugs plus a targeted therapy and chemotherapy. The goal is to see if this combination can shrink tumors …
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: Jiangsu Cancer Institute & Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New hope for hard-to-treat colon cancer: combo attack with immunotherapy and radiation
Disease control Not yet recruitingThis phase 2 study tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) and targeted radiation to a standard targeted therapy (fruquintinib) can help people with metastatic colorectal cancer that has spread to a few spots. The trial will enroll 60 adults who …
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: Huazhong University of Science and Technology • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New cocktail of four drugs takes on advanced colorectal cancer
Disease control Not yet recruitingThis phase 2 trial is testing a combination of four drugs—irinotecan liposome, capecitabine, bevacizumab, and camrelizumab—as a second or later treatment for people with metastatic colorectal cancer. The study will enroll 68 participants and measure how long the disease stays und…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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New drug combo aims to fight colorectal cancer when standard chemo fails
Disease control Not yet recruitingThis Phase 2 trial tests whether a new drug combination (fruquintinib plus trifluridine/tipiracil) works better than a standard combo (bevacizumab plus trifluridine/tipiracil) for people with advanced colorectal cancer that has not responded to standard chemotherapy. About 292 ad…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New drug cocktail aims to tackle tough gut cancers
Disease control Not yet recruitingThis Phase 2 trial will test an experimental drug called SSGJ-706 combined with standard chemotherapy (and sometimes another drug, bevacizumab) in 300 people with advanced gastrointestinal cancers that cannot be surgically removed. The goal is to see if the combination is safe an…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase 2 • Sponsor: Shenyang Sunshine Pharmaceutical Co., LTD. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Blood test may reveal hidden cancer spread without scans
Knowledge-focused Not yet recruitingThis study is testing whether a blood test can locate where colorectal cancer has returned or spread after surgery. Researchers are analyzing genetic markers in the blood to build a model that predicts whether a recurrence is local or distant. The goal is to improve early detecti…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Sponsor: The First Affiliated Hospital with Nanjing Medical University • Aim: Knowledge-focused
Last updated Jul 08, 2026 00:00 UTC