METASTATIC BREAST CARCINOMA

This early-stage trial tests the safety and best dose of combining two drugs—pidnarulex and trastuzumab deruxtecan—in people with advanced breast cancer or other solid tumors that have a protein called HER2. The study includes up to 36 adults whose cancer has spread, cannot be re…

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This study tests a radiation method that targets the entire brain and spinal cord to kill cancer cells that have spread there, while avoiding a memory-related area called the hippocampus. It is for people with breast or lung cancer that has reached the fluid and tissues around th…

This study tests an experimental treatment for people with metastatic cancers (colorectal, pancreatic, ovarian, breast, and neuroendocrine tumors) that have not responded to standard therapy. Doctors take white blood cells from a patient's tumor, grow the most cancer-fighting one…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. Participants continue their usual drug therapy while receiving SBRT. The goal is to see if this appr…

This study tests a type of radiation therapy (craniospinal irradiation) for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the disease in the central nervous system.…

This early-phase study tests a wearable device that creates low-intensity electric fields to disrupt cancer cell growth, combined with standard drugs (cabozantinib or nab-paclitaxel plus atezolizumab). About 43 adults with advanced solid tumors in the abdomen or chest that have s…

This early-phase study tests the safety and best dose of two drugs—ZEN003694 and abemaciclib—given together to people with advanced breast cancer, NUT carcinoma, or other solid tumors that have spread or can't be removed by surgery. The goal is to see if the combination can shrin…

This study tests whether combining an immunotherapy drug (cemiplimab) with a procedure that delivers tiny radioactive beads directly to liver tumors (Y90 radioembolization) can help people with breast cancer that has spread to the liver. The goal is to boost the immune system's a…

This study tests whether a precise type of radiation (SBRT) can control limited cancer growth in people with ER+ metastatic breast cancer, allowing them to continue their current medication instead of switching. It also evaluates a special PET scan (FES) to better detect where th…

This study tests if a precise type of proton radiation (pCSI) can help people with breast or lung cancer that has spread to the fluid-filled space around the brain and spinal cord live longer than standard x-ray radiation. About 115 participants will be randomly assigned to one o…

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen in premenopausal women with breast cancer. Both drugs stop the ovaries from making estrogen, which can fuel cancer growth. The trial will test if leuprolide works as well as goserelin. Ab…

This study tests whether adding another drug (cediranib or AZD6738) to the PARP inhibitor olaparib can shrink tumors or slow cancer growth in people with advanced BRCA-mutated breast cancer that has stopped responding to PARP inhibitors. About 60 adults with HER2-negative, BRCA-p…

This study is testing a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. The goal is to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study compares two types of radiation therapy for people whose cancer has spread to the brain. One group gets a single high dose of radiation, while the other gets three smaller doses over several days. The goal is to see if the three-dose approach works better at controllin…

This study looks at how well older adults (70+) with hormone receptor positive metastatic breast cancer tolerate the drug abemaciclib after other treatments have stopped working. The main goal is to track side effects and see if the drug can be safely combined with hormone therap…

This study aims to collect tumor samples and medical information from 2000 people with breast cancer that has come back or spread. Researchers will use these samples to study how the cancer changes and responds to treatments. The goal is to better understand the disease and impro…

This study is testing a new radioactive tracer called [18F]FTT to see if it can improve PET scans for people with metastatic breast cancer. The goal is to better detect whether standard treatments like PARP inhibitors (with or without immunotherapy) are working. About 22 particip…

This study follows 700 adults with advanced or metastatic breast cancer who are taking CDK4/6 inhibitors (ciclibs). Researchers collect blood, tissue, and fluid samples to understand how the cancer responds and why resistance develops. The goal is to improve treatment decisions a…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…

This study talks to 50 people with advanced breast cancer to learn what has helped them, what has been hard, and what kind of support they still need. It does not test any new drug or treatment. The goal is to design better supportive care programs for the future.

This study tests whether a portable device that creates electric fields is safe and practical for treating cancer that has spread to the lining of the spine. It includes up to 5 adults with breast or lung cancer that has spread to the spinal fluid and spine. The goal is to see if…