MELANOMA

This early-phase trial tested a new drug, DCC-3084, alone or with other treatments, in people with advanced solid tumors linked to MAPK pathway mutations (like certain lung, pancreatic, or skin cancers). The study aimed to find safe doses and check if tumors shrank. It was termin…

This study tested whether a combination of two immunotherapy drugs (nivolumab and relatlimab) works better than nivolumab alone to prevent melanoma from coming back after surgery. It involved over 1,000 adults and teens with stage III or IV melanoma that had been completely remov…

This early-stage study tested a new drug called BDC-3042, alone or with another drug (cemiplimab), in people with advanced solid tumors like breast, kidney, ovarian, head and neck, colorectal, lung cancer, or melanoma. The goal was to check safety and see if tumors shrank. The st…

This early-phase study tested a new experimental drug, PF-08046032, alone or combined with another drug (sasanlimab) in 6 adults with advanced lymphomas or solid tumors that had spread or stopped responding to standard treatments. The main goals were to check safety and find the …

This study looked at two different drug combinations for people with advanced melanoma that has a specific BRAF gene change and has gotten worse after prior treatment. One group received a targeted therapy pill (encorafenib and binimetinib) plus an immunotherapy infusion (pembrol…

This early-phase study tested a combination of two immune-boosting drugs (ipilimumab and MGN1703) in 28 patients with advanced solid tumors, including melanoma, that had stopped responding to standard treatments. The main goal was to find the safest dose of MGN1703 when given wit…

This study tested whether adding radiotherapy to the drug pembrolizumab works better than pembrolizumab alone for people with advanced melanoma. The goal was to see if the combination could slow cancer growth and even shrink tumors that were not directly treated. The trial was st…

This study tested the drug niraparib in 22 adults with advanced solid tumors (like breast, lung, or pancreatic cancer) that have a specific genetic change called a PALB2 mutation. The goal was to see if niraparib could shrink tumors or slow their growth. The study was stopped ear…

This study tested the drug imatinib in adults with ocular (eye) melanoma that had spread to other parts of the body. The goal was to see if the drug could stop or shrink tumors. Only 13 people took part before the study was stopped early.

This study tested whether taking a pill containing special gut bacteria (EDP1503) could make standard immunotherapy (pembrolizumab) work better for people with advanced melanoma. Eight adults with melanoma that could not be removed by surgery or had spread took the bacteria pill …

This study tested a biosimilar (a nearly identical copy) of the cancer drug nivolumab (Opdivo) in people with advanced melanoma that cannot be removed by surgery or has spread. The goal was to see if the biosimilar works as well and is as safe as the original drug when used with …

This study looked at a new combination of two drugs for people with metastatic melanoma (cancer that has spread). The first part aimed to find the safest dose of an experimental drug (APX005M) when given with an approved immunotherapy (pembrolizumab). The second part checked if t…

This study tested an experimental drug called BT-001, injected directly into tumors, either alone or with the immunotherapy pembrolizumab, in people with advanced solid tumors (like melanoma, lung, or breast cancer). The goal was to see if it was safe and could shrink tumors. The…

This study tested a combination of two drugs, ipilimumab and epacadostat, in people with advanced melanoma that could not be removed by surgery. The goal was to see if adding epacadostat to standard therapy improved survival. However, the study was stopped early for business reas…

This early-stage trial tested a drug called STI-3031, given directly into lymph nodes or vessels using a special device, for people with in-transit melanoma (skin cancer that has spread along lymph channels). The goal was to find a safe dose and check for side effects. Only 3 peo…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in adults with melanoma or kidney cancer that had spread to the brain. Participants had already received anti-PD-1/PD-L1 treatments. The goal was to see if the drug combo could shrink brain tumors. The st…

This study tested an experimental drug called vobramitamab duocarmazine in people with advanced prostate cancer that no longer responds to hormone therapy, as well as other solid tumors like melanoma and lung cancer. The goal was to see if the drug could shrink tumors or slow dis…

This study tested a drug called tovorafenib in people aged 12 and older with advanced solid tumors that have specific genetic changes (MAPK pathway). The goal was to see if the drug could shrink tumors. The study was stopped early, but the results may help guide future treatments…

This study tested whether adding an immunotherapy drug (PDR001) to two standard targeted therapies (dabrafenib and trametinib) could help people with advanced melanoma that has a specific gene change (BRAF V600). The trial was stopped early and did not reach its main goals. About…

This early-phase study tested a new drug called SO-C101, alone or with pembrolizumab, in 115 people with advanced solid tumors (like lung, kidney, or skin cancer) that stopped responding to standard treatments. The main goal was to check safety and find the right dose. The study …

This early-stage study tested a new drug, PF-07820435, alone or with another drug (sasanlimab), in 9 people with advanced solid tumors like lung, skin, and kidney cancers. The main goal was to check safety and find the right dose. The study was stopped early, so results are limit…

This study tested a new drug, HFB301001, in 31 adults with advanced cancers like sarcoma and melanoma. The goal was to find a safe dose and check for side effects. The trial was stopped early, so results are limited.

This study tested a new drug called PF-08046031 in 11 adults with advanced melanoma or other solid tumors that had spread or had no standard treatment. The goal was to check the drug's safety and side effects. The study was stopped early, so results are limited.

This study tested a new drug combination for people with advanced melanoma that cannot be removed by surgery or has spread. The experimental treatment involved injecting CMP-001 directly into tumors along with the immunotherapy nivolumab, compared to nivolumab alone. The study wa…

This study tested whether adding an experimental drug (NT-I7) to an existing immunotherapy (atezolizumab) could help people with advanced skin cancers like melanoma, Merkel cell carcinoma, and squamous cell carcinoma. The trial enrolled 31 adults whose cancers had not responded t…

This early-phase study tested a new medicine called PF-07921585, given alone or with another drug (sasanlimab), in adults with advanced solid tumors like lung, bladder, kidney, skin, head and neck, or colorectal cancer. The goal was to check safety and how the body handles the dr…

This study tested a new drug called modakafusp alfa, given alone or with another drug (pembrolizumab), in adults with advanced solid tumors or melanoma that had spread. The goal was to find safe doses and check for side effects. The trial was stopped early, but it aimed to see if…

This early-stage study tested an experimental oral drug called TNO155 in 227 adults with advanced solid tumors (like lung, skin, or esophageal cancer) that had stopped responding to standard treatments. The main goal was to find safe doses and understand side effects, both when g…

This study tested a vaccine called POL-103A in people with high-risk melanoma who had surgery to remove their cancer. The goal was to see if the vaccine could prevent the melanoma from coming back. About 500 people took part, but the study was stopped early. The vaccine was desig…

This study tested whether a technique called axillary reverse mapping with lympho-venous bypass could prevent lymphedema (arm swelling) in people having lymph nodes removed for breast cancer or melanoma. The approach aimed to reroute lymph fluid to reduce swelling. The study was …

This research registry looks at the health, well-being, and needs of people who survived cancer as young adults (diagnosed between ages 18 and 39). It tracks levels of anxiety, depression, social support, and financial distress by having participants fill out online surveys every…

This study looked at how high-dose radiation therapy affects the immune system in people with liver, colorectal, melanoma, or kidney cancers. Researchers took blood samples before, during, and after treatment to track immune cells and other markers. The goal was to learn more abo…