MELANOMA

This study tests a combination of three drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery to people with advanced melanoma that can be removed. The goal is to see if this approach is safe and helps shrink tumors. About 20 adults with stage III or limited stage IV…

This study looks at whether giving immunotherapy earlier in the day works better for advanced melanoma. About 108 people will be randomly assigned to morning or afternoon infusions. The goal is to see if timing improves how long the cancer stays under control, especially for wome…

This early-phase study tests a virus called DNX-2401 that is designed to infect and destroy melanoma cells. About 50 adults with stage IV melanoma that has spread to the brain or other organs will receive injections of the virus. The main goal is to find the safest dose and numbe…

This early-stage study tests whether a new drug, HLX18, works similarly to the approved cancer drug OPDIVO®. About 174 adults with esophageal cancer, melanoma, or bladder cancer who had surgery will receive either HLX18 or OPDIVO®. The goal is to compare how the drugs move throug…

This study tests whether giving two drugs (SHR-1701 and famitinib) before surgery can improve outcomes for people with a rare and aggressive skin cancer called mucosal melanoma. After surgery, treatment is tailored based on how well the tumor responded. The trial involves 70 adul…

This study compares a new drug, AVT32-DRL_PB (a biosimilar to Keytruda), with Keytruda itself in people with stage IIB/C or III melanoma that has been fully removed by surgery. About 120 adults will receive either the biosimilar or Keytruda every 3 weeks for up to 6 cycles. The g…

This study tests whether a new drug called Bmab1700 works like the approved drug Opdivo in people with melanoma (a serious skin cancer) after their tumor has been completely removed by surgery. The study will involve 120 adults with stage IIB to IV melanoma. The main goal is to c…

This is the first human study of an experimental oral drug called ACC-1898 for adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and understand how the body processes the drug. Participants will take dail…

This study tests a tool called Thrive Track for young adults aged 20-39 who have had thyroid, melanoma, or testicular cancer. The tool provides cancer information plus personalized emotional support strategies to help manage worry and distress. Researchers want to see if adding t…

This study aims to find up to 1,000 people who may qualify for one of several cancer genetics studies at the National Cancer Institute. Participants complete a 15-20 minute online survey about their personal and family cancer history. No treatments are offered; the goal is to gat…

This study looks at whether eating more fiber helps melanoma patients respond better to immunotherapy. Researchers will track the fiber intake of 60 patients and see if those who eat more fiber have less cancer recurrence or progression. The goal is to understand the link between…

This study looks at whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with certain cancers who are starting immunotherapy will take a mix of 7 common drugs to measure these effects. The goal is to understa…

This early-phase study compares an inhaled version of the cancer drug afatinib to the standard oral pill in 24 healthy adult smokers. Researchers want to see if the inhaled form delivers the drug more directly to the lungs with fewer side effects. Participants will receive both f…