LUPUS

This study tests a drug called mosunetuzumab in 30 people with lupus, with or without kidney inflammation. The goal is to see if the drug can put the disease into remission for at least 6 months after treatment ends, without needing ongoing lupus medications (except antimalarials…

This study tests whether baricitinib, a drug already approved for other immune conditions, is safe for people with Job syndrome who also have lupus-like disease or eczema. About 20 people aged 12 and older will take the pill daily for 6 months. Researchers will monitor side effec…

This early-phase study tests whether a new drug, ONTO1, is safe and tolerable for people with lupus nephritis or systemic lupus erythematosus (SLE). Researchers will also see if adding ONTO1 to standard lupus treatments can improve symptoms. The study enrolls 61 adults with activ…

This study tests a new cell therapy called CART19 for teens and young adults (ages 12-29) with severe lupus that hasn't responded to other treatments. The therapy uses the patient's own immune cells to target and reduce lupus activity. The goal is to control the disease and reduc…

This early-stage study is testing an experimental drug called BMS-986326 in 44 adults with different forms of lupus (discoid, subacute cutaneous, or systemic). The main goal is to see if the drug is safe and how the body processes it when given as multiple doses by IV or injectio…

This early-stage study tests a single injection of cells from donated umbilical cords in 10 adults with active lupus. The goal is to see if the treatment is safe and can improve kidney function and reduce disease activity when added to standard care. Participants will have regula…

This study tests a new treatment for autoimmune diseases like lupus and scleroderma. It combines a special immune cell therapy (AD-PluReceptor NK cells) with a targeted drug (tafasitamab) and chemotherapy. The goal is to find a safe dose and see if it can control the disease. Abo…

This study tests whether a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) can safely reduce chronic widespread pain in people with lupus. Thirty adults with both lupus and fibromyalgia will attend 8 weekly therapy sessions online. Researchers will c…

This study compares two online programs for people with chronic pain: an 8-week cognitive behavioral therapy course (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which approach works better for reducing pain intensity and improving daily l…

This study is creating a program to support brain health in children and teens with lupus. Researchers will work with 60 participants aged 13-18 to see if the program is practical and helpful. The goal is to improve quality of life by addressing mental and emotional well-being.

This study aims to understand the different types of fatigue people experience, whether from cancer, lupus, ME/CFS, or other conditions. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and optional brain scans. The goal …

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults to help researchers better understand conditions like lupus, celiac disease, and kidney disease. The goal is to find new biomarkers and improve future tests and treatments.…

This study is creating a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to find new markers …

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…