LOW-GRADE GLIOMA

This phase 2 trial tests a vaccine made from glioma antigen peptides combined with an immune booster (Poly-ICLC) in 25 children with recurrent low-grade gliomas that cannot be removed by surgery. The goal is to see if the vaccine can shrink tumors or keep them stable. Children wh…

This study tests a drug called mirdametinib, which is designed to reach the brain and target a key growth signal in low-grade glioma cells. It is for children, adolescents, and young adults (ages 2 to 24) whose tumor has come back or is growing. The goal is to find the best dose …

This early-stage study tests a new oral drug (PF-07799544) alone or with another drug for adults with advanced solid tumors that have a BRAF V600 mutation, including melanoma, lung, thyroid, and brain cancers. The goal is to check safety and how well the drugs work. About 124 par…

This phase 2 trial is testing whether patients with a certain type of low-grade brain tumor (BRAF V600 mutant) can safely stop or reduce their dose of two targeted drugs, dabrafenib and trametinib, after 12-24 months of treatment. About 96 participants will either stop the drugs …

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or grown after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor tissue. The main goal is to see how many…

This study tests whether a targeted drug called selumetinib works as well as standard chemotherapy (carboplatin and vincristine) for children and young adults with a slow-growing brain tumor called low-grade glioma. Participants must be 2 to 21 years old and have a tumor without …

This study is testing a new drug called tovorafenib in Japanese children, adolescents, and young adults (ages 6 months to 25 years) with a specific type of brain tumor called low-grade glioma that has come back or is growing. The drug is taken once a week by mouth. The main goals…

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This early-phase trial at Children's Hospital of Philadelphia is testing whether a radioactive tracer called 18F-Fluciclovine (Axumin) can improve PET-MRI scans for children and young adults with low-grade glioma. About 30 participants will receive the tracer before starting trea…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study tests whether special brain exercises can help adults with low-grade glioma improve memory, attention, and thinking skills that are often damaged by surgery, radiation, or chemotherapy. About 97 participants will try one of three rehab methods: in-person sessions, a co…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study aims to understand how often low-grade gliomas (slow-growing brain tumors) occur in Argentina and how long patients typically survive. Researchers will look back at medical records of about 40 patients from hospitals in Argentina. The goal is to fill a gap in knowledge…

This study collects tumor samples from 50 adults with low- or high-grade glioma to grow mini-tumors (organoids) in the lab. Researchers will study these organoids to learn why gliomas are so hard to treat and how they spread. The goal is to create personalized 'avatars' for testi…

This study tests a new MRI software that aims to take pictures of the brain much faster than current methods. It includes 300 children and adults with low-grade glioma, as well as healthy volunteers. The goal is to see if the fast scans are as clear and useful for doctors as the …