LOW-GRADE GLIOMA

This study tests a drug called mirdametinib in children, teens, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to reach the brain and block signals that help tumors grow. The goal is to find the best dose and see if it can shrink or stabilize …

This study looks at whether people with a certain type of slow-growing brain tumor (low-grade glioma with a BRAF V600 mutation) can safely stop or lower their dose of two targeted drugs (dabrafenib and trametinib) after taking them for 12-24 months. About 96 participants will eit…

This study tests a vaccine made from proteins found on glioma cells, combined with an immune booster, in children with low-grade gliomas that cannot be removed by surgery and have not responded to at least two prior treatments. The goal is to see if the vaccine can shrink the tum…

This study tests if a targeted drug called selumetinib works as well as standard chemotherapy (carboplatin and vincristine) for children and young adults with a slow-growing brain tumor called low-grade glioma. Participants must be 2 to 21 years old and have a tumor without a spe…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or worsened after prior therapy. About 40 participants will receive the laser procedure, which uses heat to destroy tumor tissue. The main goal is to s…

This study tests a new drug called tovorafenib in Japanese children, teens, and young adults (ages 6 months to 25 years) with a specific type of brain tumor (low-grade glioma) that has come back or is growing. The drug is taken as a pill once a week. The main goals are to check t…

This study tests a new cancer medicine (PF-07799544) taken as a pill, alone or with another drug, in adults with advanced solid tumors that have a specific gene change (BRAF V600). The goal is to see if the combination is safe and can shrink or control tumors. About 124 people wi…

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This study looks at whether special brain exercises can help people with low-grade glioma improve memory, attention, and thinking skills that are often damaged by surgery, radiation, or chemotherapy. About 97 adults will try one of three rehab methods (in-person, app-based, or te…

This study tests whether slowly reducing (tapering) the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, without increasing brain swelling. About 200 adults who had surgery for a brain tumor will be r…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who have memory or thinking problems. About 125 participants will receive virtual one-on-one coaching sessions over 8 weeks, learning problem-solving and relaxation techniques. The goal is to see…

This study collects tumor samples from 50 adults with low- or high-grade glioma to create living mini-tumors (organoids) in the lab. Researchers will study these organoids to learn why gliomas grow, spread, and resist treatment. The goal is to find new ways to predict and improve…

This study is testing whether a special PET-MRI scan using a tracer called 18F-Fluciclovine can help doctors see how children with low-grade gliomas (a type of brain tumor) are responding to treatment. About 30 children and young adults will get the scan before starting therapy, …

This study looks at how common low-grade gliomas (slow-growing brain tumors) are in Argentina and how long people live after diagnosis. Researchers will review medical records from 40 patients treated at major hospitals. The goal is to better understand these tumors in middle-inc…