LOW-GRADE GLIOMA

This study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink…

This study compares a new targeted drug, selumetinib, to standard chemotherapy (carboplatin/vincristine) in children and young adults (ages 2-21) with NF1-related low-grade gliomas. The goal is to see if selumetinib works as well or better at controlling tumor growth and improvin…

This study compares a new drug called DAY101 to standard chemotherapy for children and young adults (under 25) with a slow-growing brain tumor (low-grade glioma) that has a specific genetic change (RAF alteration). The goal is to see if DAY101 works better at shrinking tumors and…

This study tests a daily oral drug called trametinib in children and young adults (ages 1 month to 25 years) with low-grade brain tumors or nerve tumors that have not responded to other treatments. The goal is to see if the drug can shrink tumors or stop them from growing. The st…

This study tests if the immunotherapy drug nivolumab can stop or slow the growth of certain brain tumors (gliomas) that have IDH mutations. Researchers are especially interested in tumors with many genetic changes (hypermutator phenotype). The trial involves 62 adults who receive…

This early-stage trial tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a specific type of brain tumor (IDH-mutant glioma). The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnose…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after previous treatment. The study aims to find the highest dose that is safe and …

This study tests a precise type of radiation called proton therapy for people with slow-growing brain tumors (low-grade gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue. Abou…

This study tests whether an online mind-body program for couples can improve quality of life for people with brain tumors (glioma or metastatic brain cancer) and their partners. About 74 couples will take part. The program focuses on spiritual well-being, sleep, mood, and overall…

This study tracks a substance called 2-HG in the brains of people with a type of brain cancer (glioma) that has specific gene changes. By using special MRI scans over time, researchers hope to learn how and when these tumors become more aggressive. About 42 adults will have regul…

This study tests a camera that uses different colors of light to tell the difference between low-grade brain tumor tissue and normal brain tissue during surgery. Ten adults with suspected low-grade glioma will have the camera used during their tumor removal operation. The goal is…

This study looks at how seizures change over time in people with low grade glioma (a type of brain tumor). Researchers want to see if seizure patterns can help detect tumor changes earlier. About 100 adults with brain tumors and a history of seizures will be followed. The goal is…

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…