KIDNEY TRANSPLANTATION

This study tested whether a single dose of tocilizumab, given right before or after removing a failed kidney transplant, is safe and can reduce harmful immune reactions that make a second transplant difficult. 18 adults who needed their failed kidney removed and hoped for another…

This study tested a new drug called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could help prevent the body from rejecting the new kidney. Researchers compared different combinations of medicines to find a safer and more effective way to protect th…

This study tested a new combination of two drugs (belatacept and a proteasome inhibitor) in 5 highly sensitized kidney transplant candidates. The goal was to lower the antibodies that make it nearly impossible to find a compatible donor. The approach aims to increase the chance o…

This study tested a new medicine called ASKP1240 in 50 people who just received a kidney transplant. The goal was to see how the drug moves through the body and if it is safe. Participants received a single dose of the drug or a placebo. The study is complete and helps researcher…

This early-stage study tested a new approach to help kidney transplant recipients stop their daily anti-rejection drugs. Eight adults received donor stem cells along with a special drug combination, with the goal of safely weaning them off all immunosuppression. The main focus wa…

This study tested whether two diabetes medications, metformin and empagliflozin, can safely improve metabolic problems (like fat distribution and blood sugar) in people who received a kidney transplant. 105 adult kidney transplant recipients with good kidney function were randoml…

This study tested if adjusting the dose of the anti-rejection drug tacrolimus based on a patient's genetic makeup helps reach target blood levels faster after a kidney transplant. 280 adult kidney transplant recipients were randomly assigned to receive either a standard dose or a…

This study tested whether giving donor stem cells to kidney transplant recipients could allow them to safely stop taking anti-rejection drugs after one year. It involved 88 people receiving a kidney from a matched sibling. The goal was to see if the body would accept the new kidn…

This study tested a new drug plan for 20 kidney transplant patients to see if it could prevent organ rejection with fewer side effects. The approach used two strong antibodies right after transplant, followed by just one maintenance drug instead of the usual cocktail. The goal wa…

This study looked at 77 kidney transplant recipients who had already developed a first skin cancer (squamous cell carcinoma). Researchers wanted to see if switching their anti-rejection medication from calcineurin inhibitors to rapamycin would lower the chance of getting new skin…

This study tested a new drug called CFZ533 against the standard medicine tacrolimus to see if it could prevent kidney transplant rejection. About 418 kidney transplant patients took part. The goal was to compare how well each drug prevented rejection, graft loss, or death over 12…

This study tested a new drug called FR104 in 10 people receiving a kidney transplant for the first time. The goal was to see if FR104 is safe and can help prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study involved 81 children who had received an organ transplant (like kidney, liver, or heart) and were taking a standard anti-rejection drug called Prograf. Researchers wanted to see if switching to a longer-acting version called Advagraf was safe and worked just as well. T…

This study tested a special stent with a magnet on the end for children with urinary tract problems or kidney transplants. The goal was to see if doctors could remove the stent in the clinic without putting the child to sleep. 67 children took part, and the study checked if the m…

This study looked at 50 people who had a pancreas-kidney transplant to understand why some still have blood sugar problems. Researchers measured bile acids and gut hormones before and after transplant. The goal was to learn how the surgery changes these substances, not to test a …

This study followed 72 kidney and lung transplant patients for one year to see how hand tremors caused by anti-rejection drugs change over time. Researchers used spiral drawings and wrist-worn sensors to measure tremor severity. The goal was to better understand this common side …

This study looked at 241 kidney transplant patients to see how certain antibodies (AT1R-Ab) change before and after transplant. Researchers measured antibody levels over one year to understand their link to kidney function and rejection. The goal is to help doctors better predict…

This study looked at 300 kidney transplant recipients to see if a simple urine test could predict scarring in the new kidney. Researchers measured specific genes in urine cells during the first year after transplant. The goal was to find a non-invasive way to detect early damage,…

This study looked at small pieces of donor kidneys to see if certain substances could predict how well the organ would work after transplant. Researchers tested blood, urine, and tissue from 24 kidney transplant recipients. The goal was to find early signs of organ problems or re…