Gene-Guided drug dosing aims to improve kidney transplant outcomes
NCT ID NCT00552201
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 25 times
Summary
This study tested if adjusting the dose of the anti-rejection drug tacrolimus based on a patient's genetic makeup helps reach target blood levels faster after a kidney transplant. 280 adult kidney transplant recipients were randomly assigned to receive either a standard dose or a dose tailored to their CYP3A5 gene. The goal was to see if the personalized approach led to more patients having the right drug concentration in their blood early after transplant, potentially improving transplant success.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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CHU Angers
Angers, France
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CHU Gabriel Montpied
Clermont-Ferrand, 63003, France
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CHU Limoges - Hôpital Dupuytren
Limoges, 87042, France
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CHU Poitiers- hôpital Jean Bernard
Poitiers, 86021, France
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CHU Reims - Hôpital Maison Blanche
Reims, 51092, France
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CHU Rennes - Hôpital Pontchaillou
Rennes, 35033, France
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CHU Rouen - Hôpital de Bois-Guillaume
Bois-Guillaume, 76230, France
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CHU Strasbourg - Hospices Civils
Strasbourg, 67091, France
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CHU Tours - Hôpital Bretonneau
Tours, 37044, France
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CHU de la côté de Nacre
Caen, 14033, France
Conditions
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