ISCHEMIC HEART DISEASE

This early-stage trial tests whether injecting lab-grown heart muscle cells (made from stem cells) into the hearts of 10 people with severe heart failure is safe and can improve heart function. Participants have heart failure caused by blocked arteries and are monitored for 26 we…

This study tests a temporary heart pump placed in the main pumping chamber during high-risk coronary stenting. It includes 300 patients with severe coronary artery disease and weak heart muscle. The goal is to see if the pump reduces serious complications like heart failure, stro…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests a special stent (a small mesh tube) coated with a drug that helps keep heart arteries open. It involves 591 people in China with narrowed arteries who need a procedure to restore blood flow. The goal is to see if the stent is safe and effective at treating blocka…

This study is a registry that follows 400 people with coronary artery disease who received the ihtDEStiny drug-eluting stent during a routine procedure to open blocked heart arteries. Researchers are tracking how well the stent works over time, including rates of death, heart att…

This study tests a newer heart stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people in China with narrowed arteries. Both stents are drug-coated tubes that prop open arteries and release medicine to prevent re-blockage. The main goal is to see which stent…

This study tests whether using a special imaging tool called OCT during stent placement leads to better outcomes than standard methods for people with complex heart blockages. About 1,200 adults with stable or unstable angina or non-STEMI heart attacks are taking part. The goal i…

This study aimed to test a new gene therapy called VM202RY, injected directly into the heart, to see if it could safely improve heart function in people who recently had a heart attack. The study was planned for adults aged 19 to 75 with reduced heart pumping ability. However, th…

This study tests a new catheter system (Acolyte) to help doctors open completely blocked heart arteries in people who still have symptoms despite medication. About 115 adults will take part. The goal is to see if the device safely helps guide wires through the blockage and improv…

This study compares two ways to guide treatment for blocked heart arteries in people having a heart attack. One method uses standard X-ray dye pictures (angiography), the other adds a special camera that takes 3D images inside the artery (OCT). Researchers want to see if OCT guid…

This study looks at a new method called UFR to find significant blockages in heart arteries. It involves 112 adults with suspected heart disease. The goal is to see if UFR works as well as the current standard test (FFR) to guide treatment decisions.

This study aims to improve the quality of PET heart scans by adjusting the amount of radioactive tracer (rubidium-82) based on patient weight. Researchers will compare image quality across different weight groups in 48 adults with known or suspected heart disease. The goal is to …

This study looks at why some women with heart disease symptoms have clear major arteries but still have chest pain or stress test issues. Researchers think tiny heart vessels or blood clotting problems may be the cause. About 206 women will have extra tests during their heart cat…

This study follows over 1,000 people with suspected coronary artery disease to see if special blood flow measurements in the heart's tiny vessels can predict future heart attacks, need for repeat procedures, or hospital stays. Participants undergo standard heart catheterization w…

This study planned to test a program that would identify heart patients with social challenges (like trouble getting food or housing) and connect them to community resources to prevent hospital readmissions. It was designed for adults with heart failure or coronary artery disease…

This study looks at three different techniques (lithotripsy, super-high pressure balloon, and orbital atherectomy) used to break up hardened calcium deposits in heart arteries before placing stents. The goal is to see how these methods affect the tiny blood vessels that feed the …

This study looks at how doctors in Spain use blood-thinning drugs during heart procedures called PCI (stent placement). Researchers will track 717 patients to see which drugs are used and how well they work in everyday practice. The goal is to understand short-term safety and eff…