INFLAMMATORY BOWEL DISEASE

This study tests a program called Measurement-Based Care (MBC) for veterans with inflammatory bowel disease (IBD). The program uses regular patient surveys to help doctors spot problems early and adjust treatment between clinic visits. Researchers will compare quality of life and…

This study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers want to see how well the drug controls symptoms like diarrhea and rectal bleeding, and how it affects fatigue, quality of life, and work producti…

This study is tracking 220 adults in the UK with moderate to severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic treatment. Researchers want to see how well the drug controls symptoms and helps patients achieve remission without needing steroids. …

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This pilot study tests whether one hour of morning light therapy each day for four weeks can improve sleep and reduce gut inflammation in 30 adults with ulcerative colitis who have active inflammation and poor sleep. Participants wear a sleep tracker, complete surveys, and provid…

This study tests whether morning bright light therapy can improve gut health and quality of life in people with Crohn's disease or ulcerative colitis. Researchers will measure changes in intestinal barrier function, inflammation, and gut bacteria. The study enrolls 30 adults with…

This study tests whether a five-day diet that tricks the body into a fasting state can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptoms like stoo…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Researchers will observe up to 1,000 participants aged 0 to 75, using blood tests, tissue samples, and standard medical care. No experimental tre…

This study looks at gut bacteria and related chemicals in people who have both inflammatory bowel disease (IBD) and depression. Researchers want to find unique patterns that might explain why these two conditions often occur together. The study involves 120 adults divided into th…

This study looks at bone health in teenagers who were recently diagnosed with Crohn's disease. Researchers will use MRI scans to measure fat in the bone marrow and compare it to healthy teens. The goal is to understand if Crohn's disease affects bone strength early on, which coul…

This study looks at whether microplastics in the body can cause or worsen gut inflammation, especially in people with Crohn's disease. Researchers will measure microplastics in stool samples from pregnant women, their babies, and family members. The goal is to understand how envi…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease). The tool helps patients understand immune checkpoint inhibitor drugs and their possible side effects. Researchers wil…

This early-stage study tests the safety of a new drug called SPH7854 in 111 healthy adults. Researchers will monitor for side effects and measure how the drug moves through the body. This study does not aim to treat any disease, but the results will help guide future research for…

This study looks at the best way to give COVID-19 booster and flu vaccines to people with weakened immune systems, such as those with rheumatoid arthritis, HIV, or organ transplants. Researchers will compare giving both vaccines at the same time versus one month apart, and also t…