IMMUNODEFICIENCY

This study tests whether adding a specific type of immune cell (memory T cells) after a stem cell transplant can help prevent serious viral and fungal infections. About 100 children and young adults with blood cancers, immune disorders, or bone marrow failure will receive this ex…

This study tests whether a stem cell transplant from a healthy donor can control VEXAS syndrome, a rare and serious autoinflammatory disease. About 54 adults aged 18 to 75 who have not responded to standard treatments will receive donor stem cells after chemotherapy. The goal is …

This study looks at whether giving a combination of two antiviral drugs (remdesivir plus nirmatrelvir/r) or a longer treatment course (10 days instead of 5) can help immunocompromised people clear COVID-19 faster. About 256 adults with mild to moderate COVID-19 and weakened immun…

This study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 receive chemotherapy or radiation before the transplant to prepare their …

This study looks at whether giving a combination of two antiviral drugs (remdesivir plus nirmatrelvir/r) works better than the standard single drug for COVID-19 in people with weakened immune systems. It also tests if taking the medication for 10 days instead of 5 helps clear the…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, causes immune system problems. Researchers will measure changes in infection-fighting blood cells and antibodies in 24 patients over 6 months to a year. The goal is to understand the ris…

This study looks for genes that cause immune disorders like severe infections, allergies, or autoimmune diseases. Researchers will collect blood, cheek swabs, or skin samples from 5,000 patients and their family members. The goal is to understand these conditions better and help …