HYPOXIA

This study tests a new way to give oxygen during a lung scope (bronchoscopy) to prevent dangerously low oxygen levels. About 50 adults will receive a thin breathing tube through the nose instead of a standard airway device. The goal is to see if this method is safer and reduces b…

This study tests a new device called the COMBO Endoscopy Oropharyngeal Airway in 580 obese patients (BMI 28 or higher) undergoing sedated gastrointestinal endoscopy. The device combines oxygen support, airway management, and monitoring to reduce the risk of hypoxia (low oxygen le…

This study tests whether a newer sedative, remimazolam, combined with alfentanil, can lower the risk of low oxygen levels (hypoxia) during egg retrieval for IVF, compared to the standard propofol-alfentanil combo. About 400 women aged 18-50 will take part. The goal is to make the…

This study tests whether a high flow nasal cannula (a device that delivers oxygen through the nose) works better than a face mask for people with chest injuries who have low oxygen levels. About 100 participants will be randomly assigned to one of the two devices. The goal is to …

This study tests a redesigned breathing device that lets doctors switch between two types of airway support without extra tools. The goal is to keep oxygen levels stable and reduce breathing complications during general anesthesia. About 100 adults having planned surgery will tak…

This study compares two ways of removing a breathing tube after surgery: one with suctioning inside the windpipe and one without. The goal is to see if skipping suction prevents low oxygen levels while also reducing sore throat and coughing. About 408 adults having planned surger…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent dangerously low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. Researchers will enroll 600 adults with a STOP-Ba…

This study looks at how blood vessels in the arm respond to low oxygen levels in women at different stages of menopause. Researchers will measure blood flow in 75 healthy women who are premenopausal, perimenopausal, or postmenopausal. No treatments are given—this is an observatio…

This study looks at how the right side of the heart handles low oxygen levels, like at high altitudes, in people who have previously experienced HAPE (fluid in the lungs at altitude). Researchers will simulate altitudes of 2,500 and 4,000 meters using special gas mixtures. 18 adu…

This study looks at how the right side of the heart works when there is less oxygen, like at high altitudes. Healthy volunteers will breathe special gas mixtures that mimic altitudes of 2,500 and 4,000 meters, both at rest and during light exercise. The goal is to understand norm…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel health in the brains of inactive older adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers. The goal is to fi…

This study looks at how being at high altitude (simulated in a lab) affects mood and anxiety in people with depression or anxiety disorders, compared to healthy volunteers. Participants spend six hours in a chamber that mimics the oxygen levels at 3800 meters. The goal is to unde…

This study tests whether a training program for hospital staff can improve how oxygen levels are managed in ICU patients on breathing machines. The goal is to keep oxygen saturation between 90-96% and reduce the time patients need a ventilator. About 3,600 adults in the ICU who n…

This study aims to check how accurate pulse oximeters are when oxygen levels drop to mild, moderate, and severe low levels. Researchers will compare the device's reading with a precise blood test. The study involves 10,000 healthy adults aged 18-50 and will also look at how skin …

This study looks at whether strengthening your breathing muscles and taking nitrate supplements (like those found in beets) can help healthy adults exercise longer in low-oxygen conditions similar to high altitude. Researchers will measure how long participants can cycle before g…

This study is for people over 70 who have had hip fracture surgery and will stay in the hospital for at least 5 nights. Researchers want to see if low oxygen levels during sleep are linked to delirium (sudden confusion) and other problems like infections or heart issues. The goal…