HYPOTHYROIDISM

This study tests if Armour Thyroid, a natural thyroid hormone pill, works as well as the standard synthetic T4 medication for controlling hypothyroidism. About 2800 adults with stable hypothyroidism will switch from their current synthetic T4 to Armour Thyroid or stay on syntheti…

This study tests whether allowing more flexibility in levothyroxine dosing can improve quality of life in older adults with hypothyroidism. Researchers will enroll 228 people aged 65 and older who take daily thyroid medication. Participants will be monitored for changes in sympto…

This study looks at whether hypothyroidism caused by immune checkpoint inhibitors (a type of cancer immunotherapy) can get better after stopping the immunotherapy. Researchers want to see how many patients can safely stop taking thyroid hormone replacement (levothyroxine) and wha…

This study tests whether adding a second thyroid hormone (liothyronine) to the standard levothyroxine treatment can improve cholesterol levels and quality of life in people with hypothyroidism. About 90 adults who already take levothyroxine will be randomly assigned to one of thr…

This study looks at whether giving thyroid hormone (levothyroxine) to people on dialysis who have slightly high TSH levels can improve their quality of life, physical strength, and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for a y…

This study tests a program to help doctors safely reduce or stop thyroid hormone medication in adults 65 and older who are getting too much or don't need it. The goal is to lower the risk of harm from overtreatment. About 900 participants will take part, and the program will be e…

This study tests a decision-support tool that uses early blood tests to predict the best dose of levothyroxine (thyroid hormone) after thyroid removal. Normally, finding the right dose takes months of trial and error. The tool aims to get patients to the correct dose faster, whic…

This study looks at whether different types of strength training can improve quality of life for women with hypothyroidism. Researchers will compare two training schedules (nonlinear vs. linear) in 75 women aged 35-45 who have their condition under control. The main goal is to se…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study looks at 500 people with hypothyroidism who take levothyroxine, a common thyroid medication. The goal is to see if measuring a different thyroid hormone (fT3) or the ratio of fT3 to fT4 can give a more accurate picture of thyroid health than current tests. Researchers …

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. …