HYPERTROPHIC CARDIOMYOPATHY

This study tested whether the drug trientine can reduce heart muscle thickening and improve exercise ability in people with hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. 154 adults took either trientine or a placebo for 12 months. The goal w…

This study looked at the long-term safety of the drug mavacamten in adults with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. About 314 people who had already completed earlier studies took part. The goal was to track any side effects over time, not to…

This study tested a drug called BX1514M in 38 people with hypertrophic cardiomyopathy, a condition where the heart muscle is too thick and blocks blood flow. The drug works by tightening veins to reduce the blockage. Researchers measured how far people could walk in 6 minutes to …

This study looked at 258 adults with different types of heart muscle disease (cardiomyopathy) to see if special heart imaging could predict stroke or silent brain damage. Researchers used ultrasound and MRI to measure blood flow inside the heart. The goal was to find links betwee…

This study tested a single dose of an experimental drug called HRS-1893 in 20 healthy adults. The main goal was to see how the body processes the drug and to check for any safety issues. This is an early step before testing the drug in people with hypertrophic cardiomyopathy, a h…

This completed Phase 1 study enrolled 24 adults aged 18-65, including people with mild or moderate kidney impairment and healthy volunteers. Researchers measured how the drug HRS-1893 moves through the body and is cleared, to help determine the right dose for patients with kidney…

This small pilot study looked at 5 people with hypertrophic cardiomyopathy (thick heart muscle) who needed an implantable defibrillator to prevent dangerous heart rhythms. The goal was to see if it's possible to run a larger study comparing two types of defibrillators: one placed…